Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia.
Department of Biology, College of Science and Arts at Alkamil, University of Jeddah, Jeddah, Saudi Arabia.
Curr Pharm Des. 2024;30(14):1115-1127. doi: 10.2174/0113816128302001240321044409.
Cardiovascular diseases (CVDs) continue to exert a substantial global influence in specific areas due to population growth, aging, microbiota, and genetic/environmental factors. Drinking water has a strong impact on the health of an individual. Further, emerging evidence has highlighted the therapeutic potential and benefits of Zamzam water (Zam).
We investigated the influence of Zam on doxorubicin-induced cardiac toxicity, elucidating its consequential effects on GUT microbiota dysbiosis and hepatic and renal functions.
Male rats were categorized into four groups: Group 1 as Normal control (NC), Group 2 as Zamzam control (ZC), Group 3 Disease control (DC) and Group 4 as Therapeutic control (DZ) treated with Zam against doxorubicin-induced disease at a dose of 1mg/kg boy weight) intraperitoneally (i.p).
Significant dysbiosis in the composition of GM was observed in the DC group along with a significant decrease (p < 0.05) in serum levels of Zinc, interleukin-10 (IL-10), IL-6 and Angiotensin II (Ang II), while C-reactive protein (CRP), fibrinogen, and CKMB increased significantly (restoration of Zinc ions (0.72 ± 0.07 mcg/mL) compared to NC. Treatment with Zamzam exhibited a marked abundance of 18-times to 72% in Romboutsia, a genus of firmicutes, along with lowering of Proteobacteria in DZ followed by significant restoration of Zinc ions (0.72 ± 0.07 mcg/mL), significant (p ˂ 0.05) reduction in CRP (7.22 ± 0.39 mg/dL), CKMB (118.8 ± 1.02 U/L) and Fibrinogen (3.18 ± 0.16 mg/dL), significant (p < 0.05) increase in IL-10 (7.22 ± 0.84 pg/mL) and IL-6 (7.18 ± 0.40 pg/ml), restoration of Ang II (18.62 ± 0.50 nmol/mL/min), marked increase in renin with normal myocyte architecture and tissue orientation of kidney, and restoration of histological architecture of hepatocyte.
Zam treatment mitigated cardiac toxicity risk through the modulation of GUT microbiota and the renin-angiotensin system and tissue histology effectively.
心血管疾病（CVDs）由于人口增长、老龄化、微生物群和遗传/环境因素，在某些特定地区继续产生重大的全球影响。饮用水对个人健康有很大影响。此外，新出现的证据强调了扎姆扎姆水（Zam）的治疗潜力和益处。
我们研究了 Zam 对阿霉素诱导的心脏毒性的影响，阐明了其对肠道微生物群失调以及肝肾功能的影响。
雄性大鼠分为四组：第 1 组为正常对照组（NC），第 2 组为 Zamzam 对照组（ZC），第 3 组为疾病对照组（DC），第 4 组为治疗对照组（DZ），用 1mg/kg 体重的剂量腹腔内（i.p.）给予 Zam 对抗阿霉素诱导的疾病。
DC 组 GM 组成显著失调，血清锌、白细胞介素-10（IL-10）、IL-6 和血管紧张素 II（Ang II）水平显著降低（p < 0.05），而 C 反应蛋白（CRP）、纤维蛋白原和 CKMB 显著升高（NC 相比，锌离子水平恢复至 0.72 ± 0.07 mcg/mL）。Zamzam 治疗显示罗蒙氏菌（Firmicutes 属）的丰度显著增加 18 至 72%，同时 DZ 中的变形菌门数量降低，随后锌离子水平显著恢复（0.72 ± 0.07 mcg/mL），C 反应蛋白（CRP）（7.22 ± 0.39 mg/dL）、CKMB（118.8 ± 1.02 U/L）和纤维蛋白原（3.18 ± 0.16 mg/dL）显著降低（p < 0.05），IL-10（7.22 ± 0.84 pg/mL）和 IL-6（7.18 ± 0.40 pg/ml）显著增加（p < 0.05），Ang II（18.62 ± 0.50 nmol/mL/min）恢复，肾组织中肾素明显增加，正常肌细胞结构和组织取向，肝细胞组织学结构恢复。
Zam 通过调节肠道微生物群和肾素-血管紧张素系统以及组织病理学有效地减轻了心脏毒性风险。
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