Institute of Nephrology, Zhong Da Hospital, School of Medicine, Southeast University, Nanjing City, Jiangsu Province, China.
Centre for Nephrology, University College London (UCL) Medical School, Royal Free Campus, UK.
Int J Med Sci. 2018 May 22;15(8):816-822. doi: 10.7150/ijms.25543. eCollection 2018.
Considerable interest nowadays has focused on gut microbiota owing to their pleiotropic roles in human health and diseases. This intestinal community can arouse a variety of activities in the host and function as "a microbial organ" by generating bioactive metabolites and participating in a series of metabolism-dependent pathways. Alternations in the composition of gut microbiota, referred to as intestinal dysbiosis, are reportedly associated with several diseases, especially diabetes mellitus and its complications. Here we focus on the relationship between gut microbiota and diabetic nephropathy (DN), as the latter is one of the major causes of chronic kidney diseases. The activation of renin angiotensin system (RAS) is a critical factor to the onset of DN, and emerging data has demonstrated a provoking and mediating role of gut microbiota for this system in the context of metabolic diseases. The purpose of the current review is to highlight some research updates about the underlying interplay between gut microbiota, their metabolites, and the development and progression of DN, along with exploring innovative approaches to targeting this intestinal community as a therapeutic perspective in clinical management of DN patients.
由于肠道微生物群在人类健康和疾病中的多种作用，目前人们对其产生了浓厚的兴趣。这个肠道群落可以通过产生生物活性代谢物和参与一系列依赖代谢的途径，激发宿主的各种活动，并起到“微生物器官”的作用。肠道微生物群组成的改变，即肠道菌群失调，据报道与多种疾病有关，尤其是糖尿病及其并发症。在这里，我们重点关注肠道微生物群与糖尿病肾病（DN）的关系，因为后者是慢性肾脏病的主要原因之一。肾素血管紧张素系统（RAS）的激活是 DN 发病的一个关键因素，新出现的数据表明，在代谢性疾病中，肠道微生物群对该系统具有激发和介导作用。本综述的目的是强调一些关于肠道微生物群、其代谢物与 DN 的发生和进展之间潜在相互作用的最新研究，并探讨针对该肠道群落作为 DN 患者临床管理治疗靶点的创新方法。
