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肺栓塞后体力活动及特定患者的临床相关因素:一项横断面研究

Physical activity following pulmonary embolism and clinical correlates in selected patients: a cross-sectional study.

作者信息

Haukeland-Parker Stacey, Jervan Øyvind, Ghanima Waleed, Spruit Martijn A, Holst René, Tavoly Mazdak, Gleditsch Jostein, Johannessen Hege Hølmo

机构信息

Department of Physical Medicine and Rehabilitation, Østfold Hospital Trust, Grålum, Norway.

Institute of Clinical Medicine, University of Oslo, Oslo, Norway.

出版信息

Res Pract Thromb Haemost. 2024 Mar 5;8(2):102366. doi: 10.1016/j.rpth.2024.102366. eCollection 2024 Feb.

Abstract

BACKGROUND

There is limited knowledge regarding physical activity and clinical correlates among people who have suffered a pulmonary embolism (PE).

OBJECTIVES

To assess physical activity levels after PE and potential clinical correlates.

METHODS

One hundred forty-five individuals free of major comorbidities were recruited at a mean of 23 months (range, 6-72) after PE diagnosis. Physical activity was assessed by steps/day on the Sensewear monitor for 7 consecutive days, exercise capacity with the incremental shuttle walk test, and cardiac function with left ventricular ejection fraction (LVEF). The association between physical activity and other variables was analyzed by a mixed-effects model.

RESULTS

Participants achieved a mean of 6494 (SD, 3294; range, 1147-18.486) steps/day. The mixed-effects model showed that physical activity was significantly associated with exercise capacity (β-coefficient, 0.04; 95% CI, 0.03-0.05) and LVEF (β-coefficient, -0.81; 95% CI, -1.42 to -0.21). The analysis further showed that men became less physically active with increasing age (β-coefficient, -0.14; 95% CI, -0.24 to -0.04), whereas no change with age could be detected for women.

CONCLUSION

In selected post-PE patients, physical activity seems to be associated with exercise capacity and LVEF but not with quality of life, dyspnea, or characteristics of the initial PE. Men appear to become less physically active with increasing age.

摘要

背景

关于肺栓塞(PE)患者的身体活动及临床相关因素的了解有限。

目的

评估PE后的身体活动水平及潜在的临床相关因素。

方法

在PE诊断后平均23个月(范围6 - 72个月)招募了145名无重大合并症的个体。通过连续7天使用Sensewear监测仪测量每日步数来评估身体活动,通过递增往返步行试验评估运动能力,通过左心室射血分数(LVEF)评估心功能。采用混合效应模型分析身体活动与其他变量之间的关联。

结果

参与者每日平均步数为6494步(标准差3294;范围1147 - 18486)。混合效应模型显示,身体活动与运动能力(β系数0.04;95%置信区间0.03 - 0.05)和LVEF(β系数 - 0.81;95%置信区间 - 1.42至 - 0.21)显著相关。分析进一步表明,男性随着年龄增长身体活动减少(β系数 - 0.14;95%置信区间 - 0.24至 - 0.04),而女性未发现随年龄有变化。

结论

在选定的PE后患者中,身体活动似乎与运动能力和LVEF相关,但与生活质量、呼吸困难或初始PE的特征无关。男性似乎随着年龄增长身体活动减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/263b/10982567/e5352c4d0bb4/gr1.jpg

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