Bedini Andrea, Medioli Filippo, Gallerani Altea, Venturelli Irene, Franceschi Giacomo, Meschiari Marianna, Franceschini Erica, Maria Lima Giacomo, Sarti Mario, Mussini Cristina
Infectious Diseases Unit, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy.
Clinical Microbiology Unit, Azienda Ospedaliero-Universitaria Policlinico di Modena, Modena, Italy.
J Oral Microbiol. 2024 Mar 29;16(1):2334545. doi: 10.1080/20002297.2024.2334545. eCollection 2024.
Intravenous drug users (IDUs) have a high risk of developing skin and soft tissue infections such as erysipelas, abscesses, and less frequently necrotizing fasciitis (NF) or gas gangrene. Rarely, the cause of the infection is microorganisms residing in the oral cavity and can lead to life-threatening infections.
We describe the case of a 43-year-old man intravenous drug user (IDU) who was admitted for intense leg pain following an injection of cocaine at that site.
A clinical and radiological diagnosis of NF was made, so the patient was started on empirical antibiotic therapy and underwent surgical fasciotomy (after 8 hours from admission). was isolated from multiple intraoperative specimens and was resistant to initial antimicrobial therapy. The man, suffering from periodontal disease, reported sucking the syringe several times to unblock it. Both fasciotomy surgery and adjustment of antimicrobial therapy enabled therapeutic success.
In IDUs the risk of deep skin and soft tissue infections is high and may be aggravated by contamination with oral microorganisms. The choice of empirical antibiotic treatment should include agents active against oral cavity anaerobes, such as
静脉注射吸毒者(IDU)发生皮肤和软组织感染的风险很高,如丹毒、脓肿,较少见的有坏死性筋膜炎(NF)或气性坏疽。感染原因很少是口腔中的微生物,但可能导致危及生命的感染。
我们描述了一名43岁男性静脉注射吸毒者的病例,他因在该部位注射可卡因后出现剧烈腿部疼痛而入院。
做出了NF的临床和影像学诊断,因此患者开始接受经验性抗生素治疗,并接受了手术筋膜切开术(入院8小时后)。从多个术中标本中分离出[具体微生物名称未给出],且该菌对初始抗菌治疗耐药。该男子患有牙周病,报告称曾多次吸吮注射器以疏通堵塞。筋膜切开术和抗菌治疗的调整均取得了治疗成功。
在静脉注射吸毒者中,深部皮肤和软组织感染的风险很高,口腔微生物污染可能会加剧这种情况。经验性抗生素治疗的选择应包括对口腔厌氧菌有效的药物,如