在 COVID-19 mRNA 加强针接种 6 个月后，55.9%的个体对 XBB1.5 株的中和活性降低：来自日本福岛疫苗接种社区调查中 1353 名参与者的假病毒检测的结果。

Diminished neutralizing activity against the XBB1.5 strain in 55.9% of individuals post 6 months COVID-19 mRNA booster vaccination: insights from a pseudovirus assay on 1,353 participants in the Fukushima vaccination community survey, Japan.

机构信息

General Incorporated Association for Comprehensive Disaster Health Management Research Institute, Tokyo, Japan.

Department of Radiation Health Management, Fukushima Medical University School of Medicine, Fukushima, Fukushima, Japan.

出版信息

Front Immunol. 2024 Mar 18;15:1337520. doi: 10.3389/fimmu.2024.1337520. eCollection 2024.

DOI:10.3389/fimmu.2024.1337520

PMID:38562937

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10983612/

Abstract

This study investigates the neutralizing activity against the XBB1.5 variant and the ancestral strain in a population post-bivalent vaccination using a pseudo virus assay validated with authentic virus assay. While bivalent booster vaccination and past infections enhanced neutralization against the XBB 1.5 strain, individuals with comorbidities showed reduced responses. The study suggests the need for continuous vaccine updates to address emerging SARS-CoV-2 variants and highlights the importance of monitoring real-world immune responses.

摘要

本研究使用经真实病毒检测验证的假病毒检测法，调查了人群在接受二价疫苗加强针接种后的针对 XBB1.5 变异株和原始株的中和活性。虽然二价疫苗加强针接种和既往感染增强了针对 XBB 1.5 株的中和作用，但合并症患者的反应降低。该研究表明需要不断更新疫苗以应对新出现的 SARS-CoV-2 变异株，并强调了监测真实世界免疫反应的重要性。