Department of Dermatology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Department of Cardiology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, China.
Front Cell Infect Microbiol. 2024 Mar 18;14:1327083. doi: 10.3389/fcimb.2024.1327083. eCollection 2024.
Gut microbiota has been associated with dermatological problems in earlier observational studies. However, it is unclear whether gut microbiota has a causal function in dermatological diseases.
Thirteen dermatological diseases were the subject of bidirectional Mendelian randomization (MR) research aimed at identifying potential causal links between gut microbiota and these diseases. Summary statistics for the Genome-Wide Association Study (GWAS) of gut microbiota and dermatological diseases were obtained from public datasets. With the goal of evaluating the causal estimates, five acknowledged MR approaches were utilized along with multiple testing corrections, with inverse variance weighted (IVW) regression serving as the main methodology. Regarding the taxa that were causally linked with dermatological diseases in the forward MR analysis, reverse MR was performed. A series of sensitivity analyses were conducted to test the robustness of the causal estimates.
The combined results of the five MR methods and sensitivity analysis showed 94 suggestive and five significant causal relationships. In particular, the increased the risk of developing psoriasis vulgaris (odds ratio [OR] = 1.32, p = 4.36 × 10), (OR = 2.25, p = 4.39 × 10), (OR = 1.42, p = 1.29 × 10), and (OR = 2.25, p = 1.29 × 10) increased the risk of developing acne; and the increased the risk of urticaria (OR = 1.30, p = 9.13 × 10). A reverse MR study revealed insufficient evidence for a significant causal relationship. In addition, there was no discernible horizontal pleiotropy or heterogeneity.
This study provides novel insights into the causality of gut microbiota in dermatological diseases and therapeutic or preventive paradigms for cutaneous conditions.
在早期的观察性研究中，肠道微生物群与皮肤科问题有关。然而，肠道微生物群是否对皮肤科疾病有因果作用尚不清楚。
13 种皮肤病是双向孟德尔随机化（MR）研究的主题，旨在确定肠道微生物群与这些疾病之间的潜在因果关系。从公共数据集获得了肠道微生物群和皮肤病的全基因组关联研究（GWAS）的汇总统计数据。为了评估因果估计值，使用了五种公认的 MR 方法和多重检验校正，逆方差加权（IVW）回归作为主要方法。对于在正向 MR 分析中与皮肤病有因果关系的分类群，进行了反向 MR。进行了一系列敏感性分析以测试因果估计值的稳健性。
五种 MR 方法和敏感性分析的综合结果显示了 94 个提示性和 5 个显著的因果关系。特别是， 增加了寻常型银屑病的发病风险（优势比[OR] = 1.32，p = 4.36×10）， （OR = 2.25，p = 4.39×10）， （OR = 1.42，p = 1.29×10）和 （OR = 2.25，p = 1.29×10）增加了痤疮的发病风险； 增加了荨麻疹的发病风险（OR = 1.30，p = 9.13×10）。反向 MR 研究表明因果关系的证据不足。此外，没有明显的水平多效性或异质性。
本研究为肠道微生物群在皮肤科疾病中的因果关系以及皮肤状况的治疗或预防模式提供了新的见解。
