光氧化还原催化的酮基自由基与未稳定化的伯烷基自由基的自由基-自由基交叉偶联反应。
Photoredox-catalyzed radical-radical cross coupling of ketyl radicals with unstabilized primary alkyl radicals.
作者信息
Feng Shishen, Liu Hong, Li Yan, Fang Yewen
机构信息
Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials and Ministry-of-Education Key Laboratory for Synthesis and Application of Organic Functional Molecules, Hubei University, No. 368 YouyiDadao, Wuhan 430062, China.
School of Materials and Chemical Engineering, Ningbo University of Technology, No. 201 Fenghua Road, Ningbo 315211, China.
出版信息
Chem Commun (Camb). 2024 Apr 18;60(33):4431-4434. doi: 10.1039/d4cc00620h.
Herein, a novel protocol dealing with the preparation of sterically hindered alcohols has been successfully developed radical-radical coupling reactions enabled by mild and redox-neutral photocatalysis. With alkylsilicates as the radical precursors, a range of primary alkyl radicals bearing various functional groups could couple with a range of phthalimides and activated ketones.
在此，通过温和且氧化还原中性的光催化实现的自由基-自由基偶联反应，成功开发了一种制备位阻醇的新方法。以烷基硅酸盐作为自由基前体，一系列带有各种官能团的伯烷基自由基可与一系列邻苯二甲酰亚胺和活性酮发生偶联反应。
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