位阻 - 甲基在 mA 中的应用及其在特定基因座检测中的应用。
Steric hindrance of -methyl in mA and its application for specific loci detection.
机构信息
College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, Hubei, China.
School of Public Health, Wuhan University, Wuhan 430071, Hubei, China.
出版信息
Chem Commun (Camb). 2024 Apr 18;60(33):4479-4482. doi: 10.1039/d4cc01041h.
PMID:38564258
Abstract
We found that the methyl group of -methyladenine is able to hinder the methylation of -methyladenine at the position by DMS. Based on this, we have devised a novel method for detecting -methyladenine, which was successfully applied to identify specific mA loci in 28S rRNA.
摘要
我们发现 -甲基腺嘌呤上的甲基基团能够通过 DMS 阻碍 -甲基腺嘌呤在 位的甲基化。基于此，我们设计了一种检测 -甲基腺嘌呤的新方法，并成功应用于鉴定 28S rRNA 中的特定 mA 位点。
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