Yu Li, Xu Hongen, Xiong Hanchu, Yang Chunju, Wu Ying, Zhang Qiong
Cancer Center, Department of Nursing, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Department of Oncology, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie, Guizhou, China.
Heliyon. 2024 Sep 27;10(19):e38660. doi: 10.1016/j.heliyon.2024.e38660. eCollection 2024 Oct 15.
RNA modifications have been demonstrated to affect the function, stability, processing, and interactions of RNA, including pseudouridylation, acetylation and methylation. RNA methylation products, such as N6-methyladenosine (m6A), 5-methylcytidine (m5C), N7-methylguanosine (m7G), 2'-O-dimethyladenosine (m6Am), and N1-methyladenosine (m1A), have been reported to participate in tumorigenesis and tumor progression. The role of m6A in carcinogenesis has been well studied and summarized. In this review, we described the biological functions of m5C RNA modifications in tumorigenesis and tumor progression. Moreover, we highlighted the molecular mechanisms of m5C RNA modification in oncogenesis. Furthermore, we discussed whether targeting m5C regulator-associated genes could be a novel strategy for improving therapeutic outcomes in patients with cancer.
RNA修饰已被证明会影响RNA的功能、稳定性、加工过程及相互作用，包括假尿苷化、乙酰化和甲基化。RNA甲基化产物，如N6-甲基腺苷（m6A）、5-甲基胞嘧啶（m5C）、N7-甲基鸟苷（m7G）、2'-O-二甲基腺苷（m6Am）和N1-甲基腺苷（m1A），已被报道参与肿瘤发生和肿瘤进展。m6A在致癌作用中的作用已得到充分研究和总结。在本综述中，我们描述了m5C RNA修饰在肿瘤发生和肿瘤进展中的生物学功能。此外，我们强调了m5C RNA修饰在肿瘤发生中的分子机制。此外，我们还讨论了靶向m5C调节因子相关基因是否可能是改善癌症患者治疗效果的新策略。
