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m5C RNA修饰在癌症发生发展及治疗中的作用。

The role of m5C RNA modification in cancer development and therapy.

作者信息

Yu Li, Xu Hongen, Xiong Hanchu, Yang Chunju, Wu Ying, Zhang Qiong

机构信息

Cancer Center, Department of Nursing, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.

Department of Oncology, Zhejiang Provincial People's Hospital Bijie Hospital, Bijie, Guizhou, China.

出版信息

Heliyon. 2024 Sep 27;10(19):e38660. doi: 10.1016/j.heliyon.2024.e38660. eCollection 2024 Oct 15.

DOI:10.1016/j.heliyon.2024.e38660
PMID:39444404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11497397/
Abstract

RNA modifications have been demonstrated to affect the function, stability, processing, and interactions of RNA, including pseudouridylation, acetylation and methylation. RNA methylation products, such as N6-methyladenosine (m6A), 5-methylcytidine (m5C), N7-methylguanosine (m7G), 2'-O-dimethyladenosine (m6Am), and N1-methyladenosine (m1A), have been reported to participate in tumorigenesis and tumor progression. The role of m6A in carcinogenesis has been well studied and summarized. In this review, we described the biological functions of m5C RNA modifications in tumorigenesis and tumor progression. Moreover, we highlighted the molecular mechanisms of m5C RNA modification in oncogenesis. Furthermore, we discussed whether targeting m5C regulator-associated genes could be a novel strategy for improving therapeutic outcomes in patients with cancer.

摘要

RNA修饰已被证明会影响RNA的功能、稳定性、加工过程及相互作用，包括假尿苷化、乙酰化和甲基化。RNA甲基化产物，如N6-甲基腺苷（m6A）、5-甲基胞嘧啶（m5C）、N7-甲基鸟苷（m7G）、2'-O-二甲基腺苷（m6Am）和N1-甲基腺苷（m1A），已被报道参与肿瘤发生和肿瘤进展。m6A在致癌作用中的作用已得到充分研究和总结。在本综述中，我们描述了m5C RNA修饰在肿瘤发生和肿瘤进展中的生物学功能。此外，我们强调了m5C RNA修饰在肿瘤发生中的分子机制。此外，我们还讨论了靶向m5C调节因子相关基因是否可能是改善癌症患者治疗效果的新策略。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/badd/11497397/78040e041c2f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/badd/11497397/1f6feaf3f91f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/badd/11497397/78040e041c2f/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/badd/11497397/1f6feaf3f91f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/badd/11497397/78040e041c2f/gr2.jpg

相似文献

[1]
The role of m5C RNA modification in cancer development and therapy.

Heliyon. 2024-9-27

[2]
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[3]
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[5]
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[6]
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Front Oncol. 2023-3-9

[7]
N-methyladenosine modification in cancer biology: Current status and future perspectives.

Comput Struct Biotechnol J. 2022-11-25

[8]
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[9]
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[10]
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J Hepatocell Carcinoma. 2023-12-28

引用本文的文献

[1]
m5C RNA modification in colorectal cancer: mechanisms and therapeutic targets.

J Transl Med. 2025-8-21

[2]
Targeting epigenetic regulators as a promising avenue to overcome cancer therapy resistance.

Signal Transduct Target Ther. 2025-7-18

[3]
NSUN2 contributes to the RB malignant progression and Glycolysis by mediating the m5C methylation modification of HKDC1.

J Bioenerg Biomembr. 2025-5-27

[4]
Research Progress on Natural Products That Regulate miRNAs in the Treatment of Osteosarcoma.

Biology (Basel). 2025-1-13

[5]
Exploring Ganoderma lucidum: morphology, cultivation and market potential.

World J Microbiol Biotechnol. 2024-10-29

本文引用的文献

[1]
Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis.

Mil Med Res. 2024-4-15

[2]
A novel prognostic risk-scoring system based on mC methylation regulator-mediated patterns for glioma patients.

Mol Ther Oncol. 2024-3-5

[3]
Identification of m6A/m5C-related lncRNA signature for prediction of prognosis and immunotherapy efficacy in esophageal squamous cell carcinoma.

Sci Rep. 2024-4-8

[4]
ALYREF m5C RNA methylation reader predicts bladder cancer prognosis by regulating the tumor immune microenvironment.

Medicine (Baltimore). 2024-4-5

[5]
[Not Available].

Adv Sci (Weinh). 2024-5

[6]
Steric hindrance of -methyl in mA and its application for specific loci detection.

Chem Commun (Camb). 2024-4-18

[7]
Identification of molecular subtypes and a prognostic signature based on m6A/m5C/m1A-related genes in lung adenocarcinoma.

Sci Rep. 2024-3-30

[8]
Emerging function of main RNA methylation modifications in the immune microenvironment of digestive system tumors.

Pathol Res Pract. 2024-4

[9]
NSUN5/TET2-directed chromatin-associated RNA modification of 5-methylcytosine to 5-hydroxymethylcytosine governs glioma immune evasion.

Proc Natl Acad Sci U S A. 2024-4-2

[10]
Development and Validation of a Machine Learning Prognostic Model of m5C Related immune Genes in Lung Adenocarcinoma.

Cancer Control. 2024

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