痘病毒 A51R：微管大师和毒力大师。

Poxvirus A51R: A microtubule maestro and virulence virtuoso.

机构信息

Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA 95616, USA.

出版信息

Cell Rep. 2024 Apr 23;43(4):114050. doi: 10.1016/j.celrep.2024.114050. Epub 2024 Apr 1.

DOI:10.1016/j.celrep.2024.114050

Abstract

Seo et al. shed light on virus-host interactions as they reveal how poxvirus A51R stabilizes microtubules in infected cells, which impacts vaccinia virus virulence in mice by potentially inhibiting reactive-oxygen-species-dependent antiviral responses in macrophages.

摘要

Seo 等人揭示了痘病毒 A51R 如何稳定感染细胞中的微管，这影响了牛痘病毒在小鼠中的毒力，可能通过抑制巨噬细胞中依赖活性氧的抗病毒反应。