抗骨肉瘤单克隆抗体791T/36在原发性人骨肉瘤及其在免疫缺陷小鼠中的后续异种移植中的定位。
Localization of anti-osteogenic sarcoma monoclonal antibody 791T/36 in a primary human osteogenic sarcoma and its subsequent xenograft in immunodeprived mice.
作者信息
Pimm M V, Perkins A C, Armitage N C, Baldwin R W
出版信息
Cancer Immunol Immunother. 1985;19(1):18-21. doi: 10.1007/BF00199306.
Abstract
A primary human osteogenic sarcoma was visualized in situ by external gamma-camera imaging following administration of 131I-labelled anti-osteogenic sarcoma monoclonal antibody 791T/36. A xenograft of the tumour established in immunodeprived mice also showed localization of 131I-791T/36 determined by both gamma-camera imaging and organ distribution studies. Radiolabelled normal immunoglobulin showed no tumour localization. Expression of the 791T/36-defined antigen on xenografted tissue was further confirmed by reaction of its in vitro-cultured cells with fluorescein-labelled 791T/36 antibody.
摘要
在给予¹³¹I标记的抗骨肉瘤单克隆抗体791T/36后，通过外部γ相机成像对原发性人骨肉瘤进行了原位可视化。在免疫缺陷小鼠中建立的肿瘤异种移植模型，通过γ相机成像和器官分布研究确定，也显示出¹³¹I-791T/36的定位。放射性标记的正常免疫球蛋白未显示肿瘤定位。通过体外培养细胞与荧光素标记的791T/36抗体反应，进一步证实了791T/36定义的抗原在异种移植组织上的表达。
相似文献
1
Localization of anti-osteogenic sarcoma monoclonal antibody 791T/36 in a primary human osteogenic sarcoma and its subsequent xenograft in immunodeprived mice.抗骨肉瘤单克隆抗体791T/36在原发性人骨肉瘤及其在免疫缺陷小鼠中的后续异种移植中的定位。
Cancer Immunol Immunother. 1985;19(1):18-21. doi: 10.1007/BF00199306.
2
Interferon-alpha conjugation to human osteogenic sarcoma monoclonal antibody 791T/36.α干扰素与人骨肉瘤单克隆抗体791T/36的偶联
Cancer Immunol Immunother. 1983;15(3):210-6. doi: 10.1007/BF00199167.
3
Monoclonal antibodies for radioimmunodetection of tumours and for targeting.用于肿瘤放射免疫检测和靶向治疗的单克隆抗体。
Bull Cancer. 1983;70(2):132-6.
4
Antitumor monoclonal antibodies for radioimmunodetection of tumors and drug targeting.用于肿瘤放射免疫检测和药物靶向的抗肿瘤单克隆抗体。
Cancer Metastasis Rev. 1983;2(1):89-106. doi: 10.1007/BF00046907.
5
6
Complement-dependent cytotoxicity of anti-human osteogenic sarcoma monoclonal antibodies.抗人骨肉瘤单克隆抗体的补体依赖性细胞毒性
Br J Cancer. 1982 Oct;46(4):601-10. doi: 10.1038/bjc.1982.244.
7
In vivo radiolocalization of antiosteogenic sarcoma monoclonal antibodies in osteogenic sarcoma xenografts.抗骨肉瘤单克隆抗体在骨肉瘤异种移植瘤中的体内放射性定位
Cancer Res. 1984 May;44(5):2078-83.
8
In vivo localization of anti-osteogenic sarcoma 791T monoclonal antibody in osteogenic sarcoma xenografts.抗骨肉瘤791T单克隆抗体在骨肉瘤异种移植瘤中的体内定位
Int J Cancer. 1982 Jul 15;30(1):75-85. doi: 10.1002/ijc.2910300114.
9
Localization of an anti-CEA monoclonal antibody in colo-rectal carcinoma xenografts.抗癌胚抗原单克隆抗体在结直肠癌异种移植瘤中的定位
Cancer Immunol Immunother. 1985;19(1):8-17. doi: 10.1007/BF00199305.
10
Quantitative evaluation of the localization of a monoclonal antibody (791T/36) in human osteogenic sarcoma xenografts.单克隆抗体（791T/36）在人骨肉瘤异种移植瘤中定位的定量评估。
Eur J Cancer Clin Oncol. 1984 Apr;20(4):515-24. doi: 10.1016/0277-5379(84)90238-4.
引用本文的文献
1
Complement decay accelerating factor (DAF)/CD55 in cancer.癌症中的补体衰变加速因子（DAF）/CD55
Cancer Immunol Immunother. 2006 Aug;55(8):987-95. doi: 10.1007/s00262-006-0136-8. Epub 2006 Feb 17.
本文引用的文献
1
Use of radiolabelled monoclonal anti-CEA antibodies for the detection of human carcinomas by external photoscanning and tomoscintigraphy.使用放射性标记的抗癌胚抗原单克隆抗体通过体外光扫描和断层闪烁扫描检测人类癌症。
Immunol Today. 1981 Dec;2(12):239-49. doi: 10.1016/0167-5699(81)90011-6.
2
3
Experimental studies of tumor radioimmunodetection using antibody mixtures against carcinoembryonic antigen (CEA) and colon-specific antigen-p (CSAp).使用抗癌胚抗原（CEA）和结肠特异性抗原-p（CSAp）的抗体混合物进行肿瘤放射免疫检测的实验研究。
Int J Cancer. 1981 Jan 15;27(1):101-5. doi: 10.1002/ijc.2910270116.
4
Tumor localization of CEA-containing human tumors in nude mice by means of monoclonal anti-CEA antibodies.利用单克隆抗癌胚抗原抗体对裸鼠体内含癌胚抗原的人类肿瘤进行肿瘤定位。
Int J Cancer. 1982 Nov 15;30(5):547-52. doi: 10.1002/ijc.2910300503.
5
Imaging of human melanoma xenografts in nude mice with a radiolabeled monoclonal antibody.用放射性标记的单克隆抗体对裸鼠体内的人黑色素瘤异种移植瘤进行成像。
J Natl Cancer Inst. 1982 Oct;69(4):823-6.
6
In vivo localization of anti-osteogenic sarcoma 791T monoclonal antibody in osteogenic sarcoma xenografts.抗骨肉瘤791T单克隆抗体在骨肉瘤异种移植瘤中的体内定位
Int J Cancer. 1982 Jul 15;30(1):75-85. doi: 10.1002/ijc.2910300114.
7
Antitumour reactions of monoclonal antibody against a human osteogenic-sarcoma cell line.抗人骨肉瘤细胞系单克隆抗体的抗肿瘤反应
Br J Cancer. 1981 May;43(5):582-7. doi: 10.1038/bjc.1981.87.
8
Radiolabeled fragments of monoclonal antibodies against carcinoembryonic antigen for localization of human colon carcinoma grafted into nude mice.用于定位接种于裸鼠的人结肠癌的抗癌胚抗原单克隆抗体的放射性标记片段。
J Exp Med. 1983 Aug 1;158(2):413-27. doi: 10.1084/jem.158.2.413.
9
Preparation and properties of a drug-carrier-antibody conjugate showing selective antibody-directed cytotoxicity in vitro.一种在体外显示出选择性抗体导向细胞毒性的药物-载体-抗体偶联物的制备及其性质
Int J Cancer. 1983 May 15;31(5):661-70. doi: 10.1002/ijc.2910310520.
10
Radiolocalization of human mammary tumors in athymic mice by a monoclonal antibody.通过单克隆抗体对无胸腺小鼠体内人乳腺肿瘤进行放射性定位。
Cancer Res. 1983 Feb;43(2):736-42.
Zotero 插件