Department of Surgery, Hillman Center for Pediatric Transplantation and Thomas E. Starzl Transplantation Institute, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Division of Gastroenterology, Hepatology and Nutrition, Department of Pediatrics, UPMC Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Pediatr Transplant. 2024 May;28(3):e14744. doi: 10.1111/petr.14744.
There is limited data in the literature about pediatric kidney transplant (KT) following gut transplant (GT). The purpose of this study is to highlight the technical challenges and outcomes of KT in pediatric gut recipients who developed kidney failure (KF).
A retrospective single-center study of pediatric GT recipients from January 2000 to December 2019 was performed. In total, 14 (7%) out of 206 pediatric GT recipients developed KF and were listed for KT. Ten patients underwent kidney after gut transplant (KAGT), three patients underwent simultaneous kidney and re-do gut transplant (SKAGT), and one patient died on the KT waitlist.
1-, 5-, and 10-year kidney graft survival was 100%, 91%, and 78%, respectively. 1-, 5-, and 10-year GT graft survival was 100%, 77%, and 77%, respectively. 1-, 5-, and 10-year patient survival was 100%, 91%, and 91%, respectively.
Despite the technical complexity, KAGT and SKAGT for pediatric GT recipients that develop KF can be performed with favorable outcomes.
关于肠移植（GT）后儿科肾移植（KT）的数据有限。本研究的目的是强调在发生肾衰竭（KF）的儿科 GT 受者中进行 KT 的技术挑战和结果。
对 2000 年 1 月至 2019 年 12 月的儿科 GT 受者进行回顾性单中心研究。共有 14 名（7%）206 名儿科 GT 受者发生 KF 并被列入 KT 名单。10 名患者接受了肠后肾移植（KAGT），3 名患者接受了同时肾和重新肠移植（SKAGT），1 名患者在 KT 候补名单上死亡。
1、5 和 10 年的肾移植物存活率分别为 100%、91%和 78%。1、5 和 10 年 GT 移植物存活率分别为 100%、77%和 77%。1、5 和 10 年患者存活率分别为 100%、91%和 91%。
尽管技术复杂，但对于发生 KF 的儿科 GT 受者进行 KAGT 和 SKAGT 可以获得良好的结果。
