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下颌骨巨细胞瘤:一例报告。

Giant Cell Tumor of Mandible : A Case Report.

作者信息

Agarwal Sangeet Kumar, Agarwal Jyoti, Gupta Arushi, Dutta Vijay Bhushan

机构信息

Department of Head and Neck Oncosurgery, Sir Ganga Ram Hospital, New Delhi, India.

Department of Otorhinolaryngology, Sir Ganga Ram Hospital, New Delhi, India.

出版信息

Indian J Otolaryngol Head Neck Surg. 2024 Apr;76(2):2113-2116. doi: 10.1007/s12070-023-04431-8. Epub 2023 Dec 19.

Abstract

Giant cell tumor is locally aggressive primary benign neoplasm of bone with tendency of frequent recurrence, metastasis and malignant transformation. Because of the rarity of the disease involving mandible, no definite treatment guideline is established. Surgical treatment is the treatment of choice for giant cell tumor. Due to its proximity to vital structures including skull base, the recurrent disease associated with less invasive procedure could be difficult to manage while more invasive procedure will result in higher morbidity and complex reconstruction. Medical management with denosumab or zoledronic acid has been advocated in surgically unresectable disease. We present a rare case of giant cell tumor of mandible. Patient was a 33 years old lady who presented with gradually progressive painful swelling in chin. After exclusion of distant metastasis by F-18 FDG PET scan, she underwent en-bloc resection of the tumor with free fibula flap reconstruction. During 6 months of follow up visit patient had no recurrence.

摘要

骨巨细胞瘤是一种具有局部侵袭性的原发性骨良性肿瘤,具有频繁复发、转移和恶变的倾向。由于该疾病累及下颌骨的情况罕见,尚未建立明确的治疗指南。手术治疗是骨巨细胞瘤的首选治疗方法。由于其靠近包括颅底在内的重要结构,采用侵入性较小的手术治疗复发性疾病可能难以处理,而侵入性较大的手术则会导致更高的发病率和复杂的重建。对于无法手术切除的疾病,已提倡使用地诺单抗或唑来膦酸进行药物治疗。我们报告一例罕见的下颌骨巨细胞瘤病例。患者为一名33岁女性,表现为下巴逐渐进行性疼痛肿胀。经F-18 FDG PET扫描排除远处转移后,她接受了肿瘤整块切除并游离腓骨瓣重建。在6个月的随访期间,患者无复发。

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