Biermann Nora M, Piechl Susanna, Dinhopl Nora, Fuchs-Baumgartinger Andrea, Weissenbacher-Lang Christiane, Bertram Christof A
Clinical Department for Small Animals and Horses, University of Veterinary Medicine Vienna, Vienna, Austria.
Department for Farm Animals and Food System Science, University of Veterinary Medicine Vienna, Vienna, Austria.
Front Vet Sci. 2024 Aug 8;11:1457223. doi: 10.3389/fvets.2024.1457223. eCollection 2024.
Neoplastic processes of the mandible and their treatment are rarely reported in large animal species. Specifically, giant cell tumor of bone is an uncommon tumor in animals and has been associated in humans with locally invasive behavior and a high recurrence rate. En-bloc resection is the treatment of choice, but depending on the localization of the tumor, this may result in functional deficits. This report details the diagnostic work-up, treatment, and long-term outcome of a giant cell tumor of bone involving the rostral mandible and mandibular symphysis of a goat. Extensive rostral mandibulectomy involving the entire mandibular symphysis without surgical fixation of the hemimandibles was performed. Histological and electron microscopic findings of the tumor were consistent with a giant cell tumor of bone. Although a mutation of the H3F3A gene is considered the driver of tumor development in human giant cell tumors, using molecular analysis, this gene mutation could not be confirmed in this case. Follow-up examinations revealed spontaneous secondary fusion of both hemimandibles and no signs of tumor recurrence. Nearly 1 year after surgery, the owners reported no signs of tumor regrowth.
下颌骨的肿瘤性病变及其治疗在大型动物中鲜有报道。具体而言，骨巨细胞瘤在动物中是一种罕见的肿瘤，在人类中与局部侵袭性行为和高复发率相关。整块切除是首选的治疗方法，但根据肿瘤的位置，这可能会导致功能缺陷。本报告详细介绍了一只山羊涉及下颌骨前部和下颌联合处的骨巨细胞瘤的诊断检查、治疗及长期预后。实施了广泛的下颌骨前部切除术，包括整个下颌联合，未对半侧下颌骨进行手术固定。肿瘤的组织学和电子显微镜检查结果与骨巨细胞瘤一致。虽然H3F3A基因突变被认为是人类骨巨细胞瘤肿瘤发生的驱动因素，但通过分子分析，在本病例中未证实该基因突变。随访检查发现两侧半侧下颌骨自发继发性融合，且无肿瘤复发迹象。术后近1年，主人报告未发现肿瘤再生长迹象。
