敌友之间——Tc17细胞的产生及其在人类疾病中重要性的现有证据
Friend or Foe - Tc17 cell generation and current evidence for their importance in human disease.
作者信息
Hipp Anna Veronika, Bengsch Bertram, Globig Anna-Maria
机构信息
Clinic for Internal Medicine II, Gastroenterology, Hepatology, Endocrinology, and Infectious Diseases, University Medical Center Freiburg, Faculty of Medicine, Freiburg, Germany.
出版信息
Discov Immunol. 2023 Jul 20;2(1):kyad010. doi: 10.1093/discim/kyad010. eCollection 2023.
The term refers to interleukin 17 (IL-17)-producing CD8 T cells. While IL-17 is an important mediator of mucosal defense, it is also centrally involved in driving the inflammatory response in immune-mediated diseases, such as psoriasis, multiple sclerosis, and inflammatory bowel disease. In this review, we aim to gather the current knowledge on the phenotypic and transcriptional profile, the and generation of Tc17 cells, and the evidence pointing towards a relevant role of Tc17 cells in human diseases such as infectious diseases, cancer, and immune-mediated diseases.
该术语指的是产生白细胞介素17（IL-17）的CD8 T细胞。虽然IL-17是黏膜防御的重要介质，但它也在免疫介导疾病（如银屑病、多发性硬化症和炎症性肠病）的炎症反应驱动中起核心作用。在本综述中，我们旨在收集有关Tc17细胞的表型和转录谱、其产生和分化的当前知识，以及指向Tc17细胞在人类疾病（如传染病、癌症和免疫介导疾病）中相关作用的证据。
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