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对于母亲GBS定植进行青霉素预防后，婴儿肠道微生物群在一岁内持续减少。

Persistent reduction of in the infant gut microbiome in the first year of age following penicillin prophylaxis for maternal GBS colonization.

作者信息

Teuscher Jana Lucia, Lupatsii Mariia, Graspeuntner Simon, Jonassen Sinje, Bringewatt Arne, Herting Egbert, Stichtenoth Guido, Bossung Verena, Rupp Jan, Härtel Christoph, Demmert Martin

机构信息

Clinic for Pediatric and Adolescent Medicine, University Hospital Schleswig-Holstein, Lübeck, Germany.

Department for Infectious Diseases and Microbiology, University Hospital Schleswig-Holstein, Lübeck, Germany.

出版信息

Front Immunol. 2025 May 15;16:1540979. doi: 10.3389/fimmu.2025.1540979. eCollection 2025.

DOI:10.3389/fimmu.2025.1540979
PMID:40443663
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12119681/
Abstract

INTRODUCTION

Group B Streptococcus is a significant cause of early-onset disease in term newborns, with a global incidence of 0.41/1000 live births. Intrapartum antibiotic prophylaxis (IAP) has reduced EOD incidence by over 80%, but concerns exist about its impact on the neonatal gut microbiome and potential long-term health effects.

METHODS

This single center study examines the effects of IAP on the fecal infant microbiome in the first year of age and on the T cell phenotype in the first days after birth among 22 infants receiving IAP with penicillin due to maternal GBS colonization and 26 infants not exposed to IAP. The fecal microbiome was analyzed at birth, one month and one year of age through 16S rRNA gene sequencing. Additionally, a T cell phenotyping of peripheral blood was performed between the second and fifth day of age.

RESULTS

At one month, IAP exposed infants had a significantly lower relative abundance of Bifidobacterium longum in fecal samples, an effect which was sustained at one year. In IAP exposed infants we found a proinflammatory T-helper cell profile, characterized by higher IL-17A, RORgt, and TGF-b expression.

DISCUSSION

This study proposes a sustained impact of IAP on the neonatal microbiome and T cell repertoire.

摘要

引言

B族链球菌是足月儿早发型疾病的重要病因，全球活产儿发病率为0.41/1000。产时抗生素预防（IAP）已使早发型疾病发病率降低了80%以上，但人们担心其对新生儿肠道微生物群的影响以及潜在的长期健康效应。

方法

本单中心研究调查了22例因母亲GBS定植而接受青霉素IAP治疗的婴儿和26例未接受IAP治疗的婴儿中，IAP对1岁内婴儿粪便微生物群以及出生后数天T细胞表型的影响。通过16S rRNA基因测序分析出生时、1个月和1岁时的粪便微生物群。此外，在出生后第2天至第5天对外周血进行T细胞表型分析。

结果

1个月时，接受IAP治疗的婴儿粪便样本中长双歧杆菌的相对丰度显著降低，这种影响在1岁时持续存在。在接受IAP治疗的婴儿中，我们发现了一种促炎性辅助性T细胞谱，其特征是白细胞介素-17A、维甲酸相关孤儿受体γt和转化生长因子-β表达较高。

讨论

本研究表明IAP对新生儿微生物群和T细胞库有持续影响。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb66/12119681/e04a05855823/fimmu-16-1540979-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb66/12119681/feaa7a6f9523/fimmu-16-1540979-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb66/12119681/a48bc5001ad6/fimmu-16-1540979-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb66/12119681/5f6e168059f5/fimmu-16-1540979-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb66/12119681/9851b2872bd1/fimmu-16-1540979-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb66/12119681/e04a05855823/fimmu-16-1540979-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb66/12119681/feaa7a6f9523/fimmu-16-1540979-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb66/12119681/a48bc5001ad6/fimmu-16-1540979-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb66/12119681/5f6e168059f5/fimmu-16-1540979-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb66/12119681/9851b2872bd1/fimmu-16-1540979-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/fb66/12119681/e04a05855823/fimmu-16-1540979-g005.jpg

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