Kumari Rinku, Ranjan Rajeev, Jaiswal Pradeep, Jha Pawan K, Nethaji Kancham, Akela Ankur
Department of General Surgery, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Department of Urology, Indira Gandhi Institute of Medical Sciences, Patna, IND.
Cureus. 2024 Mar 2;16(3):e55417. doi: 10.7759/cureus.55417. eCollection 2024 Mar.
To assess the effect of gallstone disease on liver parenchyma and the prevalence and extent of liver pathology in cholelithiasis in our population at the Department of General Surgery, Indira Gandhi Institute of Medical Science (IGIMS), Patna.
The present prospective observational study was conducted on 100 either-sex patients scheduled for open or laparoscopic cholecystectomy. In all the patients, laboratory and radiological investigations were performed. An undamaged portion of the liver edge around the gallbladder fossa was selected and held by atraumatic forceps. Using sharp scissors, around 1 cm of the liver edge was taken out and sent for histopathological examination.
The mean age of the patients was 39.28 ± 13.73 years. The majority of patients were females (69%). Pain was the predominant clinical feature in 51% of the patients, followed by vomiting (21%), nausea (18%), and indigestion (10%). In 36% of cases, the liver histology was abnormal, including steatosis, fibrosis, cholestasis, portal tract infiltration, and lobular parenchymal infiltration. A significant association was found between the duration of symptoms and abnormal histology findings (P<0.0001).
Gallstone disease is associated with notable alterations in liver histology, and these changes tend to be more prevalent in individuals with a prolonged duration of symptoms.
评估胆结石疾病对肝实质的影响，以及位于巴特那英迪拉·甘地医学科学研究所（IGIMS）普通外科的我们所研究人群中胆石症患者肝脏病理的患病率和程度。
本前瞻性观察性研究对100例计划接受开腹或腹腔镜胆囊切除术的患者进行，性别不限。对所有患者均进行了实验室及影像学检查。选取胆囊窝周围肝脏边缘未受损的部分，用无损伤钳夹住。用锐利剪刀切取约1cm的肝脏边缘组织，送病理组织学检查。
患者的平均年龄为39.28±13.73岁。大部分患者为女性（69%）。51%的患者主要临床特征为疼痛，其次是呕吐（21%）、恶心（18%）和消化不良（10%）。36%的病例肝脏组织学异常，包括脂肪变性、纤维化、胆汁淤积、门管区浸润和小叶实质浸润。症状持续时间与组织学异常结果之间存在显著相关性（P<0.0001）。
胆结石疾病与肝脏组织学的显著改变有关，且这些变化在症状持续时间较长的个体中往往更为普遍。
