Separations by Shape: Molecular Shape Recognition in Liquid Chromatography.
作者信息
Sander Lane C
机构信息
National Institute of Standards and Technology (NIST), Chemical Sciences Division 100 Bureau Drive, MS 8390, Gaithersburg, MD 20899-8390, USA.
出版信息
Chromatographia. 2022;85(4). doi: 10.1007/s10337-022-04137-z.
Abstract
Molecular shape can provide a basis for chromatographic separations that is distinct from other interaction mechanisms often considered in liquid chromatography. Molecular shape recognition, or shape selectivity, is most evident for the separation of isomeric compounds that have constrained molecular structures, such as polycyclic aromatic hydrocarbons. A central feature of shape-selective columns is conformational order within the stationary phase; this aspect of stationary phase morphology is revealed through spectroscopic studies and molecular dynamics simulations, and is correlated with chromatographic performance.
摘要
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本文引用的文献
1
Characterization of triacontyl (C-30) liquid chromatographic columns.三癸基（C-30）液相色谱柱的特性。
J Chromatogr A. 2020 Mar 15;1614:460732. doi: 10.1016/j.chroma.2019.460732. Epub 2019 Nov 26.
2
Retention mechanism for polycyclic aromatic hydrocarbons in reversed-phase liquid chromatography with monomeric stationary phases.反相液相色谱中单一组分固定相保留多环芳烃的机理。
J Chromatogr A. 2011 Dec 23;1218(51):9183-93. doi: 10.1016/j.chroma.2011.10.043. Epub 2011 Oct 21.
3
Peer Reviewed: Understanding Reversed-Phase LC with solid-state NMR.同行评审：用固态 NMR 理解反相液相色谱。
Anal Chem. 1999 Nov 1;71(21):733A-41A. doi: 10.1021/ac990790z.
4
Chain order and mobility of high-density c(18) phases by solid-state NMR spectroscopy and liquid chromatography.通过固态核磁共振光谱法和液相色谱法研究高密度c(18)相的链序和流动性
Anal Chem. 1996 Dec 1;68(23):4107-13. doi: 10.1021/ac9606113.
5
Identification of isolated cavity features within molecular dynamics simulated chromatographic surfaces.
J Chromatogr A. 2006 Sep 22;1128(1-2):79-89. doi: 10.1016/j.chroma.2006.06.043. Epub 2006 Jul 18.
6
Molecular dynamics simulations of alkylsilane stationary-phase order and disorder. 2. Effects of temperature and chain length.
Anal Chem. 2005 Dec 15;77(24):7862-71. doi: 10.1021/ac051085v.
7
Molecular dynamics simulations of alkylsilane stationary-phase order and disorder. 1. Effects of surface coverage and bonding chemistry.烷基硅烷固定相有序和无序的分子动力学模拟。1. 表面覆盖率和键合化学的影响。
Anal Chem. 2005 Dec 15;77(24):7852-61. doi: 10.1021/ac0510843.
8
Effect of surface coverage on the conformation and mobility of C18-modified silica gels.表面覆盖率对C18修饰硅胶的构象和流动性的影响。
Anal Bioanal Chem. 2006 Jan;384(2):514-24. doi: 10.1007/s00216-005-0161-z. Epub 2005 Nov 29.
9
Development of engineered stationary phases for the separation of carotenoid isomers.用于分离类胡萝卜素异构体的工程固定相的开发。
Anal Chem. 1994 May 15;66(10):1667-74. doi: 10.1021/ac00082a012.
10
Order and disorder in alkyl stationary phases.
Anal Bioanal Chem. 2005 Jun;382(3):646-68. doi: 10.1007/s00216-005-3127-2. Epub 2005 Apr 13.
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