基于形状的分离：液相色谱中的分子形状识别
Separations by Shape: Molecular Shape Recognition in Liquid Chromatography.
作者信息
Sander Lane C
机构信息
National Institute of Standards and Technology (NIST), Chemical Sciences Division 100 Bureau Drive, MS 8390, Gaithersburg, MD 20899-8390, USA.
出版信息
Chromatographia. 2022;85(4). doi: 10.1007/s10337-022-04137-z.
Abstract
Molecular shape can provide a basis for chromatographic separations that is distinct from other interaction mechanisms often considered in liquid chromatography. Molecular shape recognition, or shape selectivity, is most evident for the separation of isomeric compounds that have constrained molecular structures, such as polycyclic aromatic hydrocarbons. A central feature of shape-selective columns is conformational order within the stationary phase; this aspect of stationary phase morphology is revealed through spectroscopic studies and molecular dynamics simulations, and is correlated with chromatographic performance.
摘要
分子形状可为色谱分离提供一种不同于液相色谱中通常考虑的其他相互作用机制的基础。分子形状识别，即形状选择性，在分离具有受限分子结构的异构体化合物（如多环芳烃）时最为明显。形状选择性色谱柱的一个核心特征是固定相内的构象有序性；固定相形态的这一方面通过光谱研究和分子动力学模拟得以揭示，并与色谱性能相关。
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