Division of Trauma, Critical Care, and Burn, Department of Surgery, The Ohio State University College of Medicine, Columbus, Ohio, USA.
Division of Interventional Cardiology, Department of Internal Medicine, The Ohio State University, Columbus, Ohio, USA.
Am J Hematol. 2024 Apr;99 Suppl 1(Suppl 1):S28-S35. doi: 10.1002/ajh.27296. Epub 2024 Apr 3.
Trauma-induced coagulopathy (TIC) is one of the leading causes of preventable death in injured patients. Consequently, it is imperative to understand the mechanisms underlying TIC and how to mitigate this mortality. An opportunity for advancement stems from the awareness that coagulation demonstrates a strong sex-dependent effect. Females exhibit a relative hypercoagulability compared to males, which persists after injury and confers improved outcomes. The mechanisms underlying sex dimorphisms in coagulation and its protective effect after injury have yet to be elucidated. This review explores sex dimorphisms in enzymatic hemostasis, fibrinogen, platelets, and fibrinolysis, with implications for resuscitation of patients with TIC.
创伤诱导的凝血病（TIC）是受伤患者可预防死亡的主要原因之一。因此，了解 TIC 的发病机制以及如何降低死亡率至关重要。由于凝血具有强烈的性别依赖性效应，这为进展提供了机会。与男性相比，女性表现出相对的高凝状态，这种状态在受伤后仍然存在，并带来更好的结果。凝血的性别二态性及其在受伤后的保护作用的机制尚不清楚。本综述探讨了酶止血、纤维蛋白原、血小板和纤维蛋白溶解中的性别二态性，对 TIC 患者的复苏具有重要意义。
