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与肾动脉去神经支配及器械相关的争议。

Controversies related to renal artery denervation and devices.

作者信息

Agwuegbo Chibuike Charles, Antia Akanimo Usen, Shamaki Garba Rimamskep, Bob-Manuel Tamunoinemi

机构信息

Department of Medicine, Southwest Healthcare, Temecula, California.

Department of Medicine, Lincoln Medical Center, Bronx.

出版信息

Curr Opin Cardiol. 2024 Jul 1;39(4):244-250. doi: 10.1097/HCO.0000000000001146. Epub 2024 Apr 3.

DOI:10.1097/HCO.0000000000001146
PMID:38567924
Abstract

PURPOSE OF REVIEW

This review article discusses the controversies, strengths, and limitations of the current literature on renal artery denervation in the management of resistant hypertension, as well as the future directions of this intervention.

RECENT FINDINGS

There have been conflicting data from the different randomized control trials assessing the efficacy of renal artery denervation in the management of resistant hypertension.

SUMMARY

Renal artery denervation is achieved by ablating the sympathetic nerves surrounding the renal arteries using endovascular ultrasound, radiofrequency, or alcohol. Our review article highlights that renal artery denervation is generally effective in improving blood pressure in patients with resistant hypertension. The Food and Drug Administration (FDA) has recently approved the ReCor Medical Paradise system, and the Symplicity Spyral RDN systems for renal artery denervation.

摘要

综述目的

本文综述探讨了当前关于肾动脉去神经支配术治疗顽固性高血压的文献中的争议、优势和局限性,以及该干预措施的未来方向。

最新研究发现

不同的随机对照试验评估肾动脉去神经支配术治疗顽固性高血压疗效的数据相互矛盾。

总结

肾动脉去神经支配术是通过血管内超声、射频或酒精消融肾动脉周围的交感神经来实现的。我们的综述文章强调,肾动脉去神经支配术通常对改善顽固性高血压患者的血压有效。美国食品药品监督管理局(FDA)最近已批准ReCor Medical Paradise系统和Symplicity Spyral RDN系统用于肾动脉去神经支配术。

相似文献

1
Controversies related to renal artery denervation and devices.与肾动脉去神经支配及器械相关的争议。
Curr Opin Cardiol. 2024 Jul 1;39(4):244-250. doi: 10.1097/HCO.0000000000001146. Epub 2024 Apr 3.
2
Long-Term Safety and Efficacy of Renal Denervation: 24-Month Results From the SPYRAL HTN-ON MED Trial.肾去神经术的长期安全性和有效性:SPYRAL HTN-ON MED试验的24个月结果
Circ Cardiovasc Interv. 2025 May 20;18(7):e015194. doi: 10.1161/CIRCINTERVENTIONS.125.015194.
3
Renal denervation for resistant hypertension.肾去神经术治疗顽固性高血压。
Cochrane Database Syst Rev. 2017 Feb 21;2(2):CD011499. doi: 10.1002/14651858.CD011499.pub2.
4
Twelve-month results of the rapid renal sympathetic denervation for resistant hypertension using the OneShotTM ablation system (RAPID) study.使用OneShotTM消融系统治疗顽固性高血压的快速肾交感神经去神经术(RAPID)研究的12个月结果。
EuroIntervention. 2015 Feb;10(10):1221-9. doi: 10.4244/EIJY14M12_02.
5
Efficacy and Safety of Radiofrequency-Based Renal Denervation on Resistant Hypertensive Patients: A Systematic Review and Meta-analysis.基于射频的肾脏去神经术治疗耐药性高血压患者的疗效和安全性:系统评价和荟萃分析。
High Blood Press Cardiovasc Prev. 2024 Jul;31(4):329-340. doi: 10.1007/s40292-024-00660-2. Epub 2024 Jun 19.
6
The effect of renal denervation in microcirculation: focusing on coronary microvascular dysfunction.肾去神经支配对微循环的影响:聚焦于冠状动脉微血管功能障碍。
Future Cardiol. 2025 Mar;21(4):245-256. doi: 10.1080/14796678.2025.2464478. Epub 2025 Feb 9.
7
Sympathetic Vasomotion Reflects Catheter-Based Radiofrequency Renal Denervation.交感神经血管运动反映基于导管的射频肾去神经支配。
Hypertension. 2025 Jul;82(7):1261-1270. doi: 10.1161/HYPERTENSIONAHA.125.24980. Epub 2025 May 27.
8
Cost-Effectiveness of Radiofrequency Renal Denervation in Taiwan Based on Clinical Evidence and Regional Event Rates.基于临床证据和地区事件发生率的台湾地区肾动脉射频消融术的成本效益分析
J Clin Hypertens (Greenwich). 2025 Jun;27(6):e70090. doi: 10.1111/jch.70090.
9
Renal denervation for resistant hypertension.肾动脉去神经术治疗耐药性高血压。
Cochrane Database Syst Rev. 2021 Nov 22;11(11):CD011499. doi: 10.1002/14651858.CD011499.pub3.
10
Effectiveness of renal denervation therapy for resistant hypertension: a systematic review and meta-analysis.肾去神经治疗难治性高血压的疗效:系统评价和荟萃分析。
J Am Coll Cardiol. 2013 Jul 16;62(3):231-241. doi: 10.1016/j.jacc.2013.04.010. Epub 2013 May 1.

引用本文的文献

1
A clinical prediction model for blood pressure changes after renal denervation in patients with resistant hypertension.一种用于预测顽固性高血压患者肾去神经支配术后血压变化的临床预测模型。
Front Cardiovasc Med. 2025 Jul 21;12:1637388. doi: 10.3389/fcvm.2025.1637388. eCollection 2025.