Tsang Tracey W, Allen Tiffany, Turner Angus, Bowyer Joshua, Fitzpatrick James, Latimer Jane, Oscar June, Carter Maureen, Elliott Elizabeth J
Discipline of Child and Adolescent Health, Faculty of Medicine and Health, The University of Sydney Children's Hospital Westmead Clinical School, Westmead, New South Wales, Australia.
Sydney Children's Hospital Network, Kids Research, Westmead, New South Wales, Australia.
Ophthalmic Epidemiol. 2025 Feb;32(1):61-68. doi: 10.1080/09286586.2024.2331539. Epub 2024 Apr 3.
To describe ophthalmic findings in an Indigenous paediatric population and the associations between fetal alcohol spectrum disorder (FASD), prenatal alcohol exposure (PAE), and eye anomalies.
Medical records were reviewed for eye problems, and eye assessments were conducted by an orthoptist or ophthalmologist in the Lililwan Project cohort, which comprised 108 (81%) of all children born between 2002 and 2003, and residing in the remote Fitzroy Valley, Western Australia in 2010. Values from ophthalmic assessments and prevalence of abnormalities were presented for the total cohort and stratified by group: FASD; PAE (no FASD); and No PAE.
Of children, 55% had PAE and 19% FASD. Most (98%) had normal vision; 15.6% had keratometry cylinder values indicating astigmatism and potential for improved vision with glasses. Strabismus (22.3%), short palpebral fissure length (PFL; 21.3%), upslanting palpebral fissures (12.0%), follicular trachomatous inflammation (6.9%), abnormal slit lamp assessments (6.7%), retinal tortuosity (6.7%), and blepharoptosis (5.6%) were identified. Strabismus and trachoma rates were higher than in the general child population. Ophthalmic findings were similar between groups except for prevalence of short PFL (FASD > No PAE; = 0.003); abnormal keratometry cylinder values (FASD [29.4%] and PAE (no FASD) [20.0%] > No PAE [5.3%]; = 0.031) and blepharoptosis (FASD [9.5%] > other groups [0%]; = 0.040).
Despite the small sample, some eye abnormalities were higher in children with PAE and/or FASD. Access to eye services or assessment of vision and structural eye anomalies is essential for Indigenous children, particularly those with PAE or FASD to allow early effective treatment.
描述原住民儿童群体的眼科检查结果，以及胎儿酒精谱系障碍（FASD）、产前酒精暴露（PAE）与眼部异常之间的关联。
对利利万项目队列中的儿童病历进行眼部问题审查，并由斜视矫正师或眼科医生进行眼部评估。该队列包括2002年至2003年出生且2010年居住在西澳大利亚偏远的菲茨罗伊山谷的所有儿童中的108名（81%）。呈现了整个队列以及按以下分组分层的眼科评估值和异常患病率：FASD；PAE（无FASD）；以及无PAE。
儿童中，55%有PAE，19%有FASD。大多数（98%）视力正常；15.6%的角膜曲率计柱镜值表明有散光，配镜可能改善视力。发现斜视（22.3%）、睑裂长度短（PFL；21.3%）、睑裂向上倾斜（12.0%）、滤泡性沙眼炎症（6.9%）、异常裂隙灯检查（6.7%）、视网膜迂曲（6.7%）和上睑下垂（5.6%）。斜视和沙眼发生率高于一般儿童群体。除了短PFL患病率（FASD>无PAE；P = 0.003）、异常角膜曲率计柱镜值（FASD[29.4%]和PAE（无FASD）[20.0%]>无PAE[5.3%]；P = 0.031）和上睑下垂（FASD[9.5%]>其他组[0%]；P = 0.040）外，各组的眼科检查结果相似。
尽管样本量小，但PAE和/或FASD儿童的一些眼部异常发生率较高。获得眼科服务或进行视力及眼部结构异常评估对原住民儿童至关重要，尤其是对那些有PAE或FASD的儿童，以便能尽早进行有效治疗。
