McGinniss M H, Dean A
Transfusion. 1985 Mar-Apr;25(2):105-9. doi: 10.1046/j.1537-2995.1985.25285169197.x.
We studied the red cell antigens present on K562 human leukemia cells before and after induction of hemoglobin synthesis by hemin. The fetal antigens i, IF, and IT were detected on uninduced cells. While expression of both i and IT antigens increased after hemin induction, expression of IT was closely related to fetal hemoglobin synthesis as determined in experiments in which the induction was reversed. The EnaFR, NVg, and T antigens of glycophorin A were also present on uninduced cells. In contrast, the M and Pra antigens of glycophorin A, the Kell system antigens, and the P1 antigen became detectable only after hemin induction. Antigens of other major red cell systems were not detected.
我们研究了用氯化血红素诱导血红蛋白合成前后K562人白血病细胞上存在的红细胞抗原。在未诱导的细胞上检测到胎儿抗原i、IF和IT。虽然在氯化血红素诱导后i和IT抗原的表达均增加，但IT的表达与胎儿血红蛋白合成密切相关，这在诱导逆转的实验中得到了证实。血型糖蛋白A的EnaFR、NVg和T抗原也存在于未诱导的细胞上。相比之下，血型糖蛋白A的M和Pra抗原、凯尔血型系统抗原以及P1抗原仅在氯化血红素诱导后才可检测到。未检测到其他主要红细胞系统的抗原。
