Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA.
Neurology, Mount Sinai School of Medicine, New York, New York, USA.
J Neurol Neurosurg Psychiatry. 2024 Aug 16;95(9):870-873. doi: 10.1136/jnnp-2023-333227.
Myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease (MOGAD) is a demyelinating disorder of the central nervous system. We aimed to evaluate the diagnostic performance of recently proposed MOGAD diagnostic criteria in a real-world patient cohort at a tertiary referral centre.
We identified all patients who were evaluated at Johns Hopkins and were MOG-IgG seropositive by cell-based assay. We retrospectively applied the proposed MOGAD diagnostic criteria.
Among the 122 patients included in this study, 109 fulfilled the diagnostic criteria. Of 64 patients with clear positive MOG-IgG titre, 63 patients also satisfied the supporting clinical or MRI features. Of 58 patients with low positive or unknown MOG-IgG titre, 46 met criteria by fulfilment of the supporting features. The medical records were independently reviewed by two investigators with expertise in demyelinating disease, and patients were assigned empirical clinical diagnoses, with agreement with the application of the MOGAD diagnostic criteria in the majority of cases (90%).
Our findings support the diagnostic utility of the proposed MOGAD diagnostic criteria. Patients with MOGAD met the supporting clinical or MRI features almost universally, which suggests that the criteria can be used to accurately differentiate MOGAD from mimics with low-titre MOG-IgG seropositivity.
髓鞘少突胶质细胞糖蛋白（MOG）抗体相关性疾病（MOGAD）是一种中枢神经系统脱髓鞘疾病。我们旨在评估在三级转诊中心的真实患者队列中，最近提出的 MOGAD 诊断标准的诊断性能。
我们确定了所有在约翰霍普金斯大学接受评估且通过细胞测定法呈 MOG-IgG 阳性的患者。我们回顾性地应用了拟议的 MOGAD 诊断标准。
在这项研究中，共纳入了 122 名患者，其中 109 名符合诊断标准。在 64 名 MOG-IgG 滴度明确阳性的患者中，有 63 名患者还满足支持性临床或 MRI 特征。在 58 名 MOG-IgG 滴度低阳性或未知的患者中，有 46 名患者通过满足支持性特征来满足标准。两名具有脱髓鞘疾病专业知识的研究者独立审查了病历，大多数情况下（90%），患者被分配了经验性临床诊断，与 MOGAD 诊断标准的应用一致。
我们的发现支持了拟议的 MOGAD 诊断标准的诊断效用。MOGAD 患者几乎普遍满足支持性临床或 MRI 特征，这表明该标准可用于准确区分低滴度 MOG-IgG 阳性的 MOGAD 与类似物。
