Faculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Departments of Population Health and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia.
Sci Rep. 2024 Apr 3;14(1):7854. doi: 10.1038/s41598-024-58418-8.
The relationship between body mass index (BMI) and melanoma and other skin cancers remains unclear. The objective of this study was to employ the Mendelian randomization (MR) approach to evaluate the effects of genetically predicted childhood adiposity on the risk of developing skin cancer later in life. Two-sample MR analyses were conducted using summary data from genome-wide association study (GWAS) meta-analyses of childhood BMI, melanoma, cutaneous squamous cell carcinoma (cSCC), and basal cell carcinoma (BCC). We used the inverse-variance-weighted (IVW) methods to obtain a pooled estimate across all genetic variants for childhood BMI. We performed multiple sensitivity analyses to evaluate the potential influence of various assumptions on our findings. We found no evidence that genetically predicted childhood BMI was associated with risks of developing melanoma, cSCC, or BCC in adulthood (OR, 95% CI: melanoma: 1.02 (0.93-1.13), cSCC 0.94 (0.79-1.11), BCC 0.97 (0.84-1.12)). Our findings do not support the conclusions from observational studies that childhood BMI is associated with increased risks of melanoma, cSCC, or BCC in adulthood. Intervening on childhood adiposity will not reduce the risk of common skin cancers later in life.
体质指数（BMI）与黑色素瘤和其他皮肤癌之间的关系尚不清楚。本研究的目的是采用孟德尔随机化（MR）方法来评估遗传预测的儿童肥胖对成年后患皮肤癌风险的影响。使用来自儿童 BMI、黑色素瘤、皮肤鳞状细胞癌（cSCC）和基底细胞癌（BCC）的全基因组关联研究（GWAS）荟萃分析的汇总数据，进行了两样本 MR 分析。我们使用逆方差加权（IVW）方法，对所有遗传变异进行了儿童 BMI 的综合估计。我们进行了多种敏感性分析，以评估各种假设对我们发现的潜在影响。我们没有发现遗传预测的儿童 BMI 与成年后患黑色素瘤、cSCC 或 BCC 的风险相关的证据（OR，95%CI：黑色素瘤：1.02（0.93-1.13），cSCC 0.94（0.79-1.11），BCC 0.97（0.84-1.12））。我们的研究结果不支持观察性研究的结论，即儿童 BMI 与成年后患黑色素瘤、cSCC 或 BCC 的风险增加有关。干预儿童肥胖不会降低成年后患常见皮肤癌的风险。
