用安吖啶和大剂量阿糖胞苷治疗急性髓细胞白血病：一项II期试验
[Treatment of acute myeloid leukemia with amsacrine and high-dose cytosine arabinoside: a phase II trial].
作者信息
Marit G, David B, Reiffers J, Broustet A
出版信息
Bull Cancer. 1985;72(1):37-41.
PMID:3857082
Abstract
Ten patients with acute myeloid leukaemia on failure or relapse were treated by Amsacrine and high-dose (12 g/m2) Cytosine Arabinosyl (phase II trial). Four patients achieved complete remission, over six months in one instance. Hematologic toxicity was important but extra-hematologic toxicity was mild. These two drugs could be used as induction or reinforcement treatment in acute myeloid leukaemia.
摘要
十例急性髓系白血病失败或复发患者接受了安吖啶和高剂量（12 g/m²）阿糖胞苷治疗（II期试验）。四名患者实现完全缓解，其中一例缓解持续超过六个月。血液学毒性较为严重，但血液外毒性较轻。这两种药物可用于急性髓系白血病的诱导或强化治疗。
相似文献
1
2
Sequentially administered 5-azacitidine and amsacrine in refractory adult acute leukemia: a phase I-II trial of the Southeastern Cancer Study Group.
Cancer Treat Rep. 1985 Jul-Aug;69(7-8):807-11.
3
[Clinical activity of m-Amsa and the combination of m-Amsa with cytosine arabinoside].[米托蒽醌的临床活性以及米托蒽醌与阿糖胞苷联合用药的临床活性]
Nouv Presse Med. 1982 Oct 9;11(39):2911-4.
4
Randomized trial of high-dose cytarabine versus amsacrine in acute myelogenous leukemia in relapse: a Leukemia Intergroup Study.
Cancer Treat Rep. 1986 Apr;70(4):455-9.
5
Treatment of acute leukemia with amsacrine and high-dose cytarabine.用安吖啶和大剂量阿糖胞苷治疗急性白血病。
Cancer Treat Rep. 1985 Sep;69(9):1001-2.
6
Phase II trial of amsacrine plus intermediate-dose Ara-C (IDAC) with or without etoposide as salvage therapy for refractory or relapsed acute leukemia.安吖啶联合中剂量阿糖胞苷（IDAC），联合或不联合依托泊苷作为难治性或复发性急性白血病挽救治疗的II期试验。
Jpn J Clin Oncol. 2005 Oct;35(10):612-6. doi: 10.1093/jjco/hyi149. Epub 2005 Sep 19.
7
Phase II study of amsacrine and high-dose cytarabine for resistant acute myelogenous leukemia.安吖啶与大剂量阿糖胞苷治疗难治性急性髓系白血病的II期研究。
Cancer Treat Rep. 1987 Sep;71(9):881-2.
8
[Combination of AMSA-high dose cytosine arabinoside in acute leukemia].
Presse Med. 1985 Jun 29;14(26):1417-20.
9
Modulation of cytosine arabinoside (ara-C) and high-dose ara-C in acute leukemia.急性白血病中阿糖胞苷（ara-C）及大剂量阿糖胞苷的调控作用
Semin Oncol. 1985 Jun;12(2 Suppl 3):139-43.
Zotero 插件