Alfred E. Mann Department of Biomedical Engineering, University of Southern California, 1042 Downey Way, Los Angeles, 90089, CA, USA.
Division of Biokinesiology and Physical Therapy, University of Southern California, 1540 Alcazar St 155, Los Angeles, 90033, CA, USA.
J Neuroeng Rehabil. 2024 Apr 3;21(1):46. doi: 10.1186/s12984-024-01324-x.
We present an overview of the Conference on Transformative Opportunities for Modeling in Neurorehabilitation held in March 2023. It was supported by the Disability and Rehabilitation Engineering (DARE) program from the National Science Foundation's Engineering Biology and Health Cluster. The conference brought together experts and trainees from around the world to discuss critical questions, challenges, and opportunities at the intersection of computational modeling and neurorehabilitation to understand, optimize, and improve clinical translation of neurorehabilitation. We organized the conference around four key, relevant, and promising Focus Areas for modeling: Adaptation & Plasticity, Personalization, Human-Device Interactions, and Modeling 'In-the-Wild'. We identified four common threads across the Focus Areas that, if addressed, can catalyze progress in the short, medium, and long terms. These were: (i) the need to capture and curate appropriate and useful data necessary to develop, validate, and deploy useful computational models (ii) the need to create multi-scale models that span the personalization spectrum from individuals to populations, and from cellular to behavioral levels (iii) the need for algorithms that extract as much information from available data, while requiring as little data as possible from each client (iv) the insistence on leveraging readily available sensors and data systems to push model-driven treatments from the lab, and into the clinic, home, workplace, and community. The conference archive can be found at (dare2023.usc.edu). These topics are also extended by three perspective papers prepared by trainees and junior faculty, clinician researchers, and federal funding agency representatives who attended the conference.
我们介绍了 2023 年 3 月举行的神经康复建模变革机遇会议的概况。该会议得到了美国国家科学基金会工程生物学和健康集群残疾与康复工程 (DARE) 计划的支持。会议汇集了来自世界各地的专家和学员，讨论了计算建模与神经康复交叉领域的关键问题、挑战和机遇，以了解、优化和改进神经康复的临床转化。我们围绕建模的四个关键、相关且有前途的重点领域（适应性和可塑性、个性化、人机交互和“野外”建模）组织了会议。我们确定了重点领域之间的四个共同主题，如果得到解决，可以在短期、中期和长期内推动进展。这些主题是：（i）需要捕获和管理开发、验证和部署有用计算模型所需的适当和有用的数据；（ii）需要创建跨越从个体到群体以及从细胞到行为水平的个性化范围的多尺度模型；（iii）需要能够从可用数据中提取尽可能多信息的算法，同时从每个客户那里尽可能少地要求数据；（iv）坚持利用现成的传感器和数据系统将基于模型的治疗从实验室推向临床、家庭、工作场所和社区。会议档案可在 (dare2023.usc.edu) 找到。这些主题还由参加会议的学员和初级教员、临床研究人员以及联邦资助机构代表撰写的三篇观点论文扩展。
