Luan Yu-Yong, Li Jin-Ye, Shi Wei-Yu, Zhang Zhe, Jiao Rui-Qiang, Chen Xi, Liu Xue-Yuan, Liang Yong-Min
State Key Laboratory of Applied Organic Chemistry, School of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China.
Org Lett. 2024 Apr 19;26(15):3213-3217. doi: 10.1021/acs.orglett.4c00806. Epub 2024 Apr 4.
With in-depth research on 1,2-difunctionalization, remote difunctionalization has garnered widespread attention for achieving multifunctionality. Herein, we report a strategy for achieving remote difunctionalization under mild conditions. This strategy exhibited good substrate suitability and functional group tolerance. In addition, the significance of this method is further evidenced by its successful application in scaling up and conducting additional transformations of target compounds. Mechanistic studies showed that a radical might be involved in this process.
随着对1,2-双官能化的深入研究，远程双官能化因其能够实现多功能性而受到广泛关注。在此，我们报道了一种在温和条件下实现远程双官能化的策略。该策略表现出良好的底物适用性和官能团耐受性。此外，该方法在目标化合物的放大合成及进行进一步转化中的成功应用，进一步证明了其重要性。机理研究表明，该过程可能涉及一个自由基。
