Hoch-Ligeti C, Wagner B P, Deringer M K, Stewart H L
J Natl Cancer Inst. 1985 Apr;74(4):909-15.
Feeding N,N'-2,7-fluorenylenebisacetamide (CAS:304-28-9) at 0.025% to 15 male and 15 female mastomys considerably shortened their life-span. At death every treated mastomys had several primary tumors; untreated animals at comparable ages had none. Several mastomys with hepatoblastomas and 1 with giant cell hepatitis and a metastasizing pancreatic carcinoma are first reported here. The tumor load per animal averaged 4.0 for treated females, 2.6 for treated males, 1.5 for untreated females, and 0.6 for untreated males. Of 24 hepatic tumors in treated mastomys, 11 metastasized, compared to none of the incipient tumors in 8 of 26 untreated animals. Pancreatic adenomas developed in 27 treated and 1 untreated mastomys, and a metastasizing adenocarcinoma developed in 1 treated animal. All treated females, 3 treated males, and 1 untreated female developed multiple villous adenomas in the small intestine. One untreated female and 8 treated females developed mammary cancers, 4 of which metastasized. Primary tumors of other sites occurred infrequently.
以0.025%的剂量给15只雄性和15只雌性非洲巨鼠喂食N,N'-2,7-芴撑双乙酰胺（CAS:304-28-9），显著缩短了它们的寿命。每只接受治疗的非洲巨鼠死亡时都有多个原发性肿瘤；同龄的未治疗动物则没有。本文首次报道了几只患有肝母细胞瘤的非洲巨鼠、1只患有巨细胞肝炎和转移性胰腺癌的非洲巨鼠。每只动物的肿瘤负荷，接受治疗的雌性平均为4.0，接受治疗的雄性为2.6，未治疗的雌性为1.5，未治疗的雄性为0.6。在接受治疗的非洲巨鼠的24个肝脏肿瘤中，有11个发生了转移，而26只未治疗动物中的8只的初期肿瘤均未发生转移。27只接受治疗的非洲巨鼠和1只未治疗的非洲巨鼠发生了胰腺腺瘤，1只接受治疗的动物发生了转移性腺癌。所有接受治疗的雌性、3只接受治疗的雄性和1只未治疗的雌性在小肠中发生了多发性绒毛状腺瘤。1只未治疗的雌性和8只接受治疗的雌性发生了乳腺癌，其中4例发生了转移。其他部位的原发性肿瘤很少发生。
