University of Health Sciences, Ankara Atatürk Sanatoryum Education and Research Hospital, Department of General Surgery, Ankara, Turkey.
University of Health Sciences, Dr. Abdurrahman Yurtaslan Ankara Onkoloji Education and Research Hospital, Department of Endocrinology and Metabolism, Ankara, Turkey.
Clinics (Sao Paulo). 2024 Apr 3;79:100352. doi: 10.1016/j.clinsp.2024.100352. eCollection 2024.
The aim of this study was to compare metabolic parameters, plasma Osteopontin (OPN) and Hepatocyte Growth Factor (HGF) levels between Sleeve Gastrectomy (SG) patients in their 6 post-operation month and healthy control patients.
Height, weight, Body Mass Index (BMI) and laboratory parameters of 58 SG patients aged 18‒65 years (Group 1) and 46 healthy control patients (Group 2) were compared. In addition, preoperative and postoperative sixth-month BMI and laboratory parameters of the patients in Group 1 were compared.
The mean age and gender distributions of the groups were similar (p > 0.05). Mean BMI was 28.9 kg/m in Group 1 and 27 kg/m in Group 2 (p < 0.01). While plasma HGF levels were similar between both groups, plasma OPN levels were higher in Group 2 (p < 0.001). Fasting plasma glucose, total cholesterol, triglyceride, fasting plasma insulin and insulin resistance values were higher in Group 1, while alanine aminotransferase and aspartate aminotransferase levels were higher in Group 2 (p < 0.05). There was a strong correlation between plasma HGF and OPN levels in Group 1, but not in Group 2 (Rho = 0.805, p < 0.001).
OPN and HGF are promising biomarkers that can be used to better understand and detect problems related to obesity. The fact that patients in the early post-SG period had lower plasma OPN and similar plasma HGF compared to non-surgical patients of similar age and gender with higher BMI may be another favorable and previously unknown metabolic effect of SG.
本研究旨在比较袖状胃切除术（SG）术后 6 个月患者与健康对照组患者的代谢参数、血浆骨桥蛋白（OPN）和肝细胞生长因子（HGF）水平。
比较了 58 名年龄在 18-65 岁的 SG 患者（第 1 组）和 46 名健康对照组患者（第 2 组）的身高、体重、体重指数（BMI）和实验室参数。此外，还比较了第 1 组患者术前和术后第 6 个月的 BMI 和实验室参数。
两组的平均年龄和性别分布相似（p>0.05）。第 1 组的平均 BMI 为 28.9kg/m，第 2 组为 27kg/m（p<0.01）。虽然两组间血浆 HGF 水平相似，但第 2 组的血浆 OPN 水平较高（p<0.001）。第 1 组的空腹血糖、总胆固醇、甘油三酯、空腹胰岛素和胰岛素抵抗值较高，而第 2 组的丙氨酸氨基转移酶和天冬氨酸氨基转移酶水平较高（p<0.05）。第 1 组中 HGF 和 OPN 水平之间存在强烈相关性，但第 2 组中无相关性（Rho=0.805，p<0.001）。
OPN 和 HGF 是有前途的生物标志物，可用于更好地了解和检测与肥胖相关的问题。SG 术后早期患者的血浆 OPN 水平较低，而与年龄和性别相似但 BMI 较高的非手术患者的血浆 HGF 水平相似，这可能是 SG 的另一种有利且以前未知的代谢效应。
