Department of Neurology, Hospital Weser-Egge, Brenkhaeuser Str. 71, Hoexter 37671, Germany; Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany.
Department of Neurology, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany; Evangelical Hospital Unna, Holbeinstr. 10, Unna 59423, Germany; EVEX Medical Corporation, 3 Vekua Street, Tiblisi, Republic of Georgia.
Neurol Clin. 2024 May;42(2):497-506. doi: 10.1016/j.ncl.2023.12.005. Epub 2024 Jan 8.
Identification of substances that may cause or trigger headache is important to start effective treatment early to prevent unnecessary suffering, deterioration in quality of life, and the development of chronic pain. Treatment in case of medication overuse and other chronic headache should be decisive and effective. Drug withdrawal and introduction of effective prophylactic medication for the underlying headache disorder should be the primary treatment strategy. Typical headache-inducing substances are nitric oxide, phosphodiesterase, cocaine, alcohol, histamine, carbon oxide, and calcitonin gene-related peptide. The withdrawal of caffeine, estrogen, and opioids is most often associated with the development of headache.
确定可能导致或引发头痛的物质对于早期开始有效治疗以预防不必要的痛苦、生活质量恶化和慢性疼痛的发展非常重要。药物过度使用和其他慢性头痛的治疗应该果断和有效。药物戒断和引入针对潜在头痛障碍的有效预防药物应是主要的治疗策略。典型的引起头痛的物质有一氧化氮、磷酸二酯酶、可卡因、酒精、组胺、一氧化碳和降钙素基因相关肽。咖啡因、雌激素和阿片类药物的戒断最常与头痛的发展有关。
