Department of Musculoskeletal Surgery of Shanghai Cancer Center, Fudan University, Shanghai, 200032, P. R. China.
Department of Orthopedics, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200080, P. R. China.
J Nanobiotechnology. 2024 Apr 4;22(1):151. doi: 10.1186/s12951-024-02400-z.
As the lethal bone tumor, osteosarcoma often frequently occurs in children and adolescents with locally destructive and high metastasis. Distinctive kinds of nanoplatform with high therapeutical effect and precise diagnosis for osteosarcoma are urgently required. Multimodal optical imaging and programmed treatment, including synergistic photothermal-chemodynamic therapy (PTT-CDT) elicits immunogenetic cell death (ICD) is a promising strategy that possesses high bio-imaging sensitivity for accurate osteosarcoma delineating as well as appreciable therapeutic efficacy with ignorable side-effects.
In this study, mesoporous Cu and Ce based oxide nanoplatform with Arg-Gly-Asp (RGD) anchoring is designed and successfully constructed. After loading with indocyanine green, this nanoplatform can be utilized for precisely targeting and efficaciously ablating against osteosarcoma via PTT boosted CDT and the closely following ICD stimulation both in vitro and in vivo. Besides, it provides off-peak fluorescence bio-imaging in the second window of near-infrared region (NIR II, 1000-1700 nm) and Magnetic resonance signal, serves as the dual-mode contrast agents for osteosarcoma tissue discrimination.
Tumor targeted Cu&Ce based mesoporous nanoplatform permits efficient osteosarcoma suppression and dual-mode bio-imaging that opens new possibility for effectively diagnosing and inhibiting the clinical malignant osteosarcoma.
成骨肉瘤是一种致命的骨肿瘤，常发生于儿童和青少年，具有局部破坏性和高转移性。迫切需要具有高治疗效果和精确诊断的新型纳米平台来治疗成骨肉瘤。多模态光学成像和程序化治疗，包括协同光热化学动力学治疗（PTT-CDT）引发免疫遗传细胞死亡（ICD），是一种很有前途的策略，具有高生物成像灵敏度，可准确描绘成骨肉瘤，同时具有可观的治疗效果和可忽略的副作用。
在本研究中，设计并成功构建了具有 Arg-Gly-Asp（RGD）锚定的介孔 Cu 和 Ce 基氧化物纳米平台。该纳米平台负载吲哚菁绿后，可通过 PTT 增强的 CDT 以及紧随其后的 ICD 刺激，在体外和体内实现对成骨肉瘤的精确靶向和有效消融。此外，它还提供了近红外二区（NIR II，1000-1700nm）的非峰值荧光生物成像和磁共振信号，作为成骨肉瘤组织区分的双模式对比剂。
肿瘤靶向的 Cu&Ce 介孔纳米平台可有效抑制成骨肉瘤，同时进行双模式生物成像，为有效诊断和抑制临床恶性成骨肉瘤开辟了新的可能性。
