小鼠红白血病细胞中快速珠蛋白表达的同步化
Synchronization of rapid globin expression in murine erythroleukemic cells.
作者信息
Zucker R M
出版信息
Res Commun Chem Pathol Pharmacol. 1985 Feb;47(2):301-4.
PMID:3857701
Abstract
The addition of butyric acid (BA) to murine erythroleukemia cells (MELC) produces the expression of primarily A and E2 hemoglobins while DMSO incubation produces the expression of primarily A hemoglobin. Preincubation of MELC with DMSO followed by BA induction accelerates the expression of hemoglobins in a synchronous manner, yielding the preferential synthesis of alpha and y globins, and E2 hemoglobin.
摘要
向小鼠红白血病细胞（MELC）中添加丁酸（BA）主要产生A和E2血红蛋白的表达，而二甲基亚砜（DMSO）孵育主要产生A血红蛋白的表达。先用DMSO预孵育MELC，然后进行BA诱导，可同步加速血红蛋白的表达，优先合成α和γ珠蛋白以及E2血红蛋白。
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