Yang Yang, Hou Xinwei, Wang Chen, Chen Qinming, Lu Yi, Yu Daiyue, Wu Kai
Department of Pediatric Surgery, Zhujiang Hospital, Southern Medical University, Guangzhou, 510282, Guangdong, China.
Noncoding RNA Res. 2024 Feb 28;9(3):704-714. doi: 10.1016/j.ncrna.2024.02.015. eCollection 2024 Sep.
Hirschsprung's disease (HSCR) is a congenital disorder characterized by the absence of ganglion cells in the colon, leading to various intestinal complications. The etiology of HSCR stems from complex genetic and environmental interactions, of which the intricate roles of non-coding RNAs (ncRNAs) are a key area of research. However, the roles of ncRNAs in the pathogenesis of HSCR have not been fully elucidated. In order to understand the variety of symptoms caused by HSCR and develop new therapeutic approaches, it is essential to understand the underlying biological genetic basis of HSCR. This review presents a comprehensive overview of the current understanding regarding the involvement of ncRNAs in HSCR, including microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and circular RNAs (circRNAs). Additionally, it provides a summary of the molecular mechanisms through which ncRNAs regulate the expression of genes related to the proliferation, migration, and differentiation of intestinal neural crest cells, thereby contributing to the advancement of HSCR research.
先天性巨结肠症（HSCR）是一种先天性疾病，其特征是结肠中缺乏神经节细胞，可导致各种肠道并发症。HSCR的病因源于复杂的基因与环境相互作用，其中非编码RNA（ncRNA）的复杂作用是一个关键研究领域。然而，ncRNA在HSCR发病机制中的作用尚未完全阐明。为了了解HSCR引起的各种症状并开发新的治疗方法，了解HSCR潜在的生物遗传基础至关重要。本综述全面概述了目前对ncRNA参与HSCR的理解，包括微小RNA（miRNA）、长链非编码RNA（lncRNA）和环状RNA（circRNA）。此外，还总结了ncRNA调节与肠神经嵴细胞增殖、迁移和分化相关基因表达的分子机制，从而推动HSCR研究的进展。
