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酒精性肝病与减重手术:当前观点与未来方向

Alcohol associated liver disease and bariatric surgery: Current perspectives and future directions.

作者信息

Cooper Katherine M, Colletta Alessandro, Hebda Nicholas, Devuni Deepika

机构信息

Department of Medicine, UMass Chan Medical School, Worcester, MA 01655, United States.

Division of Gastroenterology, UMass Chan Medical School, Worcester, MA 01655, United States.

出版信息

World J Gastrointest Surg. 2024 Mar 27;16(3):650-657. doi: 10.4240/wjgs.v16.i3.650.

Abstract

Bariatric surgery is a routinely performed procedure and is associated with a reduction in all-cause mortality in patients with obesity. However, bariatric surgery has also been linked to increased alcohol use with up to 30% of these patients developing alcohol use disorder (AUD). The mechanism of AUD after bariatric surgery is multifactorial and includes anatomic, metabolic, and neurohumoral changes associated with post-surgical anatomy. These patients are at increased risk of alcohol associated liver disease and, in some cases, require liver transplantation. In this article, we provide a scoping review of epidemiology, pathophysiology, and clinical outcomes of alcohol-related health conditions after bariatric surgery.

摘要

减肥手术是一种常规实施的手术,与肥胖患者的全因死亡率降低相关。然而,减肥手术也与酒精使用增加有关,这些患者中高达30%会发展为酒精使用障碍(AUD)。减肥手术后AUD的机制是多因素的,包括与术后解剖结构相关的解剖学、代谢和神经体液变化。这些患者患酒精性肝病的风险增加,在某些情况下,需要进行肝移植。在本文中,我们对减肥手术后与酒精相关的健康状况的流行病学、病理生理学和临床结果进行了范围综述。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6e9c/10989338/b6a690c0c8af/WJGS-16-650-g001.jpg

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