Dwivedi Shailendra, Sharma Praveen, Goel Apul, Khattri Sanjay, Misra Sanjeev, Pant Kamlesh Kumar
Department of Biochemistry, All India Institute of Medical Sciences, Gorakhpur, 273008 India.
Department of Biochemistry, All India Institute of Medical Sciences, Jodhpur, 243005 India.
Indian J Clin Biochem. 2024 Apr;39(2):241-247. doi: 10.1007/s12291-023-01112-9. Epub 2023 Jan 13.
Multiple diseases and disorders are connected with occupational and environmental exposure risk. It is also well-established that chemicals and chemical mixtures have an influence on the immune cells of humans. This is an important field of research that has been pursued extensively in relation to autoimmune illnesses, allergy/asthma, and lung cancer, but Prostate Carcinoma has received rare reports. Chronic chemical exposure is known to produce inflammation, which is one of the most prominent characteristics of all malignancies. Changes in the ratio of pro-inflammatory to anti-inflammatory molecules are thought to be a key factor in the emergence of inflammation. Prostate gland cells express the pro-inflammatory cytokine interleukin-18 (IL-18), which is a major facilitator of immunological responses. Conversely, interleukin-10 (IL-10) is an anti-inflammatory cytokine that is linked to immune responses and inhibits the development of an inflammatory environment. Our goal is to investigate the inflammatory status of IL-18 (pro-) and IL-10 (anti-) in a variety of occupationally exposed populations in patients with Benign Prostate Hyperplasia (BPH) and patients with Prostate Carcinoma. The present study was conducted with 664 subjects, comprising 285 Prostate Carcinoma patients, 94 BPH patients and 285 controls. The subjects of BPH and Prostate Carcinoma were screened and confirmed on the basis of Prostate Serum Antigen (PSA) and pathological biopsy. All subjects were categorized as per their occupational exposure into various groups. The pro-inflammatory and anti-inflammatory Interleukins (IL-18 and IL-10) and serum PSA levels were analysed by using corresponding quantitative ELISA kits. The results showed that as compared to control participants, the serum PSA levels were higher in the Prostate Carcinoma and BPH groups. When mean levels of IL-18 were compared between various occupational groups, Tanners (tanning industry), Agriculture, and Ordnance workers had significantly higher levels ( < 0.05) of IL-18 than sedentary workers. The pro-inflammatory cytokine (IL-18) levels were also found to be aggravated in Prostate Carcinoma compared to BPH and controls. According to the findings of the current study, the levels of inflammatory cytokines (IL-18 and IL-10) in various occupational groups of BPH, Prostate Carcinoma, and controls were altered. Long-term occupational exposure may have a negative influence on inflammation levels and the immune system; therefore, preventative measures should be explored for improved health.
多种疾病和病症与职业及环境暴露风险相关。化学物质和化学混合物对人体免疫细胞有影响这一点也已得到充分证实。这是一个重要的研究领域，在自身免疫性疾病、过敏/哮喘和肺癌方面已进行了广泛研究，但关于前列腺癌的报道却很少。已知长期接触化学物质会引发炎症，而炎症是所有恶性肿瘤最显著的特征之一。促炎分子与抗炎分子比例的变化被认为是炎症发生的关键因素。前列腺腺细胞表达促炎细胞因子白细胞介素 - 18（IL - 18），它是免疫反应的主要促进因子。相反，白细胞介素 - 10（IL - 10）是一种抗炎细胞因子，与免疫反应相关并抑制炎症环境的形成。我们的目标是研究良性前列腺增生（BPH）患者和前列腺癌患者中各种职业暴露人群的IL - 18（促炎）和IL - 10（抗炎）的炎症状态。本研究共纳入664名受试者，包括285名前列腺癌患者、94名BPH患者和285名对照。BPH和前列腺癌受试者根据前列腺特异性抗原（PSA）和病理活检进行筛查和确诊。所有受试者根据其职业暴露情况分为不同组。使用相应的定量ELISA试剂盒分析促炎和抗炎白细胞介素（IL - 18和IL - 10）以及血清PSA水平。结果显示，与对照参与者相比，前列腺癌组和BPH组的血清PSA水平更高。当比较不同职业组之间IL - 18的平均水平时，制革工人（制革行业）、农业工人和军械工人的IL - 18水平显著高于久坐不动的工人（<0.05）。与BPH和对照相比，前列腺癌患者中促炎细胞因子（IL - 18）水平也更高。根据本研究结果，BPH、前列腺癌和对照的不同职业组中炎症细胞因子（IL - 18和IL - 10）水平发生了改变。长期职业暴露可能对炎症水平和免疫系统产生负面影响；因此，应探索预防措施以改善健康状况。
