Department of Bioscience and Bioengineering, Indian Institute of Technology, Bombay, India.
Nanotheranostics. 2024 Mar 25;8(3):330-343. doi: 10.7150/ntno.93206. eCollection 2024.
Atomic Force Microscopy (AFM) is a very flexible method that can create topographical images from a range of materials and image surfaces. Significantly, AFM has emerged as an invaluable tool for dissecting the morphology and biochemical aspects of body cells and tissues. The high-resolution imaging capabilities of AFM enable researchers to discern alterations in cell morphology and understand the underlying mechanisms of diseases. It contributes to understanding disease etiology and progression. In the context of this review, our focus will be directed towards elucidating the pivotal role of AFM in analysis of blood related disorders. Through detailed comparisons with normal cells, we delve into the alterations in size, shape, and surface characteristics induced by conditions such as cancer, diabetes, anaemia, and infections caused by pathogens. In essence, various work described in this article highlights to bridge the gap between traditional microscopy and in-depth analysis of blood-related pathologies, which in turn offers valuable perspectives for both research and clinical applications in the field.
原子力显微镜（AFM）是一种非常灵活的方法，可以从各种材料和图像表面创建形貌图像。重要的是，AFM 已成为剖析体细胞和组织形态和生化方面的宝贵工具。AFM 的高分辨率成像能力使研究人员能够辨别细胞形态的变化，并了解疾病的潜在机制。它有助于了解疾病的病因和进展。在本文的讨论中，我们将重点阐述 AFM 在分析与血液相关疾病方面的关键作用。通过与正常细胞的详细比较，我们深入研究了癌症、糖尿病、贫血和病原体感染等情况下大小、形状和表面特征的变化。本质上，本文中描述的各种工作都强调了在传统显微镜和血液相关病理学的深入分析之间架起桥梁，这反过来为该领域的研究和临床应用提供了有价值的视角。
