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国际空间站上一例实验室确诊的带状疱疹/皮炎病例之前的免疫系统失调。

Immune system dysregulation preceding a case of laboratory-confirmed zoster/dermatitis on board the International Space Station.

作者信息

Mehta Satish K, Suresh Rahul, Brandt Keith, Diak Douglass M, Smith Scott M, Zwart Sara R, Douglas Grace, Nelman-Gonzalez Mayra, Clemett Simon, Brunstetter Tyson, Crucian Brian E

机构信息

JES Tech, Houston, Tex.

National Aeronautics and Space Administration, Houston, Tex.

出版信息

J Allergy Clin Immunol Glob. 2024 Mar 13;3(2):100244. doi: 10.1016/j.jacig.2024.100244. eCollection 2024 May.

DOI:10.1016/j.jacig.2024.100244
PMID:38577482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10992860/
Abstract

A case report detailing, for the first time, a case of laboratory-confirmed zoster in an astronaut on board the International Space Station is presented. The findings of reduced T-cell function, cytokine imbalance, and increased stress hormones which preceded the event are detailed. Relevance for deep space countermeasures is discussed.

摘要

首次详细介绍了一例国际空间站上一名宇航员经实验室确诊患带状疱疹的病例报告。详细阐述了该事件发生前T细胞功能降低、细胞因子失衡和应激激素增加的情况。并讨论了其与深空应对措施的相关性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1fd/10992860/2a4e2ec0665d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1fd/10992860/e7882ef0b38f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1fd/10992860/2a4e2ec0665d/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1fd/10992860/e7882ef0b38f/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e1fd/10992860/2a4e2ec0665d/gr2.jpg

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本文引用的文献

1
Dermatitis during Spaceflight Associated with HSV-1 Reactivation.航天飞行相关单纯疱疹病毒 1 型再激活致皮炎。
Viruses. 2022 Apr 11;14(4):789. doi: 10.3390/v14040789.
2
Countermeasures-based Improvements in Stress, Immune System Dysregulation and Latent Herpesvirus Reactivation onboard the International Space Station - Relevance for Deep Space Missions and Terrestrial Medicine.基于对策的国际空间站上压力、免疫系统失调和潜伏性疱疹病毒激活的改善——对深空任务和地面医学的意义。
Neurosci Biobehav Rev. 2020 Aug;115:68-76. doi: 10.1016/j.neubiorev.2020.05.007. Epub 2020 May 25.
3
Zoster patients on earth and astronauts in space share similar immunologic profiles.
暴露于空气传播的月球尘埃的大鼠的肺部和全身免疫改变。
Front Immunol. 2025 Feb 6;16:1538421. doi: 10.3389/fimmu.2025.1538421. eCollection 2025.
4
, or spaceflight-induced thymic involution.或太空飞行引起的胸腺退化。
Front Immunol. 2025 Jan 24;15:1534444. doi: 10.3389/fimmu.2024.1534444. eCollection 2024.
带状疱疹患者和太空中的宇航员具有相似的免疫特征。
Life Sci Space Res (Amst). 2020 May;25:119-128. doi: 10.1016/j.lssr.2019.10.001. Epub 2019 Oct 14.
4
Specific Immunologic Countermeasure Protocol for Deep-Space Exploration Missions.深空探测任务的特异性免疫对策方案
Front Immunol. 2019 Oct 11;10:2407. doi: 10.3389/fimmu.2019.02407. eCollection 2019.
5
Space flight-associated neuro-ocular syndrome (SANS).太空飞行相关神经眼科综合征（SANS）
Eye (Lond). 2018 Jul;32(7):1164-1167. doi: 10.1038/s41433-018-0070-y. Epub 2018 Mar 12.
6
Alterations in adaptive immunity persist during long-duration spaceflight.在长期太空飞行期间，适应性免疫会持续发生改变。
NPJ Microgravity. 2015 Sep 3;1:15013. doi: 10.1038/npjmgrav.2015.13. eCollection 2015.
7
Latent virus reactivation in astronauts on the international space station.国际空间站上宇航员体内潜伏病毒的重新激活。
NPJ Microgravity. 2017 Apr 12;3:11. doi: 10.1038/s41526-017-0015-y. eCollection 2017.
8
Incidence of clinical symptoms during long-duration orbital spaceflight.长期轨道太空飞行期间临床症状的发生率。
Int J Gen Med. 2016 Nov 3;9:383-391. doi: 10.2147/IJGM.S114188. eCollection 2016.
9
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