Paolino V J, Kashket S
Arch Oral Biol. 1985;30(4):359-63. doi: 10.1016/0003-9969(85)90011-1.
Extracts of defatted cocoa inhibited the biosynthesis of extracellular polysaccharide by both cell-free and cell-associated streptococcal glucosyltransferases, but did not affect growth or acid production. Both water-insoluble and water-soluble polysaccharide syntheses were inhibited, and the net result was a shift away from adherence-supportive polysaccharide. Inhibition was non-competitive with respect to sucrose. The inhibition of polysaccharide biosynthesis was observed also with Actinomyces species. The findings suggest that the inhibitory effects of cocoa on plaque accumulation and caries formation are due to inhibition of bacterial polysaccharide production.
脱脂可可提取物可抑制无细胞和细胞相关的链球菌葡糖基转移酶介导的细胞外多糖生物合成，但不影响细菌生长或产酸。水不溶性和水溶性多糖的合成均受到抑制，最终结果是减少了有助于黏附的多糖。这种抑制作用对蔗糖而言是非竞争性的。在放线菌属中也观察到了对多糖生物合成的抑制作用。这些发现表明，可可对牙菌斑积聚和龋齿形成的抑制作用是由于其对细菌多糖产生的抑制。
