Wang Jinping, Liu Hui, Wei Xinchuan
Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu 610041, China.
Department of Anesthesiology, West China Second University Hospital-Tianfu, Sichuan University, Meishan 620500, China.
Psychiatry Res. 2024 May;335:115890. doi: 10.1016/j.psychres.2024.115890. Epub 2024 Apr 2.
This systematic review and meta-analysis aimed to evaluate the impact of intraoperative and/or postoperative esketamine application on the prevention of postpartum depression (PPD). PubMed, Embase, and Web of Science were thoroughly searched for eligible randomized controlled trials (RCTs) regarding the application of esketamine for postnatal depression prevention. Nine RCTs including 1277 participants were involved in the final analysis. It was found that intraoperative and/or postoperative administration of esketamine significantly reduced the PPD incidence and the Edinburgh Postnatal Depression Scores in the early postoperative period. Meanwhile, esketamine lowered the occurrence of postoperative nausea and vomiting with no influence on other psychiatric symptoms.
本系统评价和荟萃分析旨在评估术中及/或术后应用艾司氯胺酮对预防产后抑郁症（PPD）的影响。通过全面检索PubMed、Embase和Web of Science，以查找关于应用艾司氯胺酮预防产后抑郁症的符合条件的随机对照试验（RCT）。最终分析纳入了9项RCT，共1277名参与者。结果发现，术中及/或术后给予艾司氯胺酮可显著降低术后早期的PPD发生率和爱丁堡产后抑郁评分。同时，艾司氯胺酮降低了术后恶心和呕吐的发生率，且对其他精神症状无影响。
