Department of Biology, University of Padua, Padua, Italy.
Department of Biology, University of Padua, Padua, Italy.
Trends Cancer. 2024 Jun;10(6):541-556. doi: 10.1016/j.trecan.2024.03.004. Epub 2024 Apr 4.
Metastasis has a major part in the severity of disease and lethality of cancer. Circulating tumour cells (CTCs) represent a reservoir of metastatic precursors in circulation, most of which cannot survive due to hostile conditions in the bloodstream. Surviving cells colonise a secondary site based on a combination of physical, metabolic, and oxidative stress protection states required for that environment. Recent advances in CTC isolation methods and high-resolution 'omics technologies are revealing specific metabolic pathways that support this selection of CTCs. In this review, we discuss recent advances in our understanding of CTC biology and discoveries of adaptations in metabolic pathways during their selection. Understanding these traits and delineating mechanisms by which they confer acquired resistance or vulnerability in CTCs is crucial for developing successful prognostic and therapeutic strategies in cancer.
转移在疾病的严重程度和癌症的致命性中起着重要作用。循环肿瘤细胞 (CTC) 代表循环中转移前体的储库，其中大多数由于血液中恶劣的条件而无法存活。存活的细胞根据在该环境中所需的物理、代谢和氧化应激保护状态在继发性部位定植。最近在 CTC 分离方法和高分辨率“组学”技术方面的进展揭示了支持这种 CTC 选择的特定代谢途径。在这篇综述中，我们讨论了我们对 CTC 生物学的理解的最新进展，以及在它们的选择过程中代谢途径适应性的发现。了解这些特征，并阐明它们在 CTC 中赋予获得性耐药性或易感性的机制，对于制定癌症的成功预后和治疗策略至关重要。
