Division of Gastroenterology, Hepatology, and Nutrition, The Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Department of Internal Medicine, University of Kentucky College of Medicine, Lexington, Kentucky, USA.
Gastrointest Endosc. 2024 Aug;100(2):262-272.e1. doi: 10.1016/j.gie.2024.04.002. Epub 2024 Apr 5.
Although pancreatic endotherapy (PET) is commonly used for treating adverse events of chronic pancreatitis, data on the frequency and factors associated with the use of PET are limited. Our aim was to define the use of and factors predictive for receiving PET in a well-characterized chronic pancreatitis cohort.
This is a cross-sectional analysis of data from PROCEED, a multicenter U.S. cohort study of chronic pancreatitis. PET modalities primarily consisted of ERCP. A treatment course was defined as the number of sessions performed for a specific indication. A repeat course was defined as PET >1 year after completion of the last course. Multivariable logistic regression identified predictive factors for receiving PET, and proportional rates model assessed risk factors for repeat PET.
Of 681 subjects, 238 (34.9%) received PET. Factors associated with receiving PET included female sex (odds ratio [OR], 1.26; 95% confidence interval [CI], 1.03-1.53), lower education (OR, 1.30; 95% CI, 1.04-1.62), income ≤$50,000 per year (OR, 1.35; 95% CI, 1.07-1.71), and prior acute pancreatitis (OR, 1.74; 95% CI, 1.31-2.32). Of 238 subjects, 103 (43.3%) underwent repeat PET at a median duration of 2 years, with 23.1% receiving 2 courses, 9.7% receiving 3 courses, and 10.4% receiving ≥4 courses.
Nearly half of patients with chronic pancreatitis who undergo PET received 1 or more repeat courses within 2 to 3 years. In addition to a prior history of acute pancreatitis, demographic and socioeconomic factors were associated with receiving PET.
尽管胰腺内镜治疗（PET）常用于治疗慢性胰腺炎的不良事件，但有关其使用频率和相关因素的数据有限。我们的目的是在一个特征明确的慢性胰腺炎队列中定义 PET 的使用情况和预测因素。
这是对美国多中心慢性胰腺炎队列研究 PROCEED 的数据分析的横断面研究。PET 方式主要包括 ERCP。治疗疗程定义为针对特定适应证进行的治疗次数。重复疗程定义为最后一次疗程完成后 1 年以上的 PET。多变量逻辑回归确定接受 PET 的预测因素，比例风险模型评估重复 PET 的危险因素。
在 681 名患者中，有 238 名（34.9%）接受了 PET。接受 PET 的相关因素包括女性（比值比[OR]，1.26；95%置信区间[CI]，1.03-1.53）、较低的教育程度（OR，1.30；95% CI，1.04-1.62）、收入≤$50,000/年（OR，1.35；95% CI，1.07-1.71）和既往急性胰腺炎（OR，1.74；95% CI，1.31-2.32）。在 238 名患者中，有 103 名（43.3%）在中位时间为 2 年时进行了重复 PET，其中 23.1%接受了 2 个疗程，9.7%接受了 3 个疗程，10.4%接受了≥4 个疗程。
近一半接受 PET 的慢性胰腺炎患者在 2 至 3 年内接受了 1 次或多次重复疗程。除了既往有急性胰腺炎病史外，人口统计学和社会经济学因素与接受 PET 有关。
