Yuan X W, Nan Y M
Department of Traditional and Western Medical Hepatology, Third Hospital of Hebei Medical University, Provincial Key Laboratory of Study on Mechanism of Hepatic Fibrosis in Chronic Liver Disease, Shijiazhuang 050051, China.
Zhonghua Gan Zang Bing Za Zhi. 2024 Mar 20;32(3):262-267. doi: 10.3760/cma.j.cn501113-20240223-00089.
Non-alcoholic fatty liver disease (NAFLD) has gradually become the most prevalent chronic liver disease in the world, but its pathogenesis has not been fully elucidated. Ferroptosis is a novel type of programmed cell death caused by iron-dependent lipid peroxidation. Heme oxygenase-1 is a recognized antioxidant enzyme and an important regulatory factor in ferroptosis that modulates ferroptosis through various pathways and, in turn, regulates NAFLD. This paper reviews the regulatory mechanism of heme oxygenase-1 on NAFLD in ferroptosis pathway, with a view to clarifying the occurrence and development mechanisms of NAFLD and providing new vision and targets for its prevention and treatment.
非酒精性脂肪性肝病（NAFLD）已逐渐成为全球最普遍的慢性肝病，但其发病机制尚未完全阐明。铁死亡是一种由铁依赖性脂质过氧化引起的新型程序性细胞死亡。血红素加氧酶-1是一种公认的抗氧化酶，也是铁死亡中的一个重要调节因子，它通过多种途径调节铁死亡，进而调控非酒精性脂肪性肝病。本文综述了血红素加氧酶-1在铁死亡途径中对非酒精性脂肪性肝病的调控机制，以期阐明非酒精性脂肪性肝病的发生发展机制，并为其防治提供新的思路和靶点。
Zhonghua Gan Zang Bing Za Zhi. 2024-3-20
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