Xi'an Medical University, Xi'an, China.
Southampton National Institute for Health Research Biomedical Research Centre, University Hospital Southampton, Southampton General Hospital, Southampton, UK.
Liver Int. 2022 Jul;42(7):1496-1502. doi: 10.1111/liv.15163. Epub 2022 Jan 23.
Non-alcoholic fatty liver disease (NAFLD), recently re-defined and re-classified as metabolic dysfunction-associated fatty liver disease (MAFLD), has become increasingly prevalent and emerged as a public health problem worldwide. To date, the precise pathogenic mechanisms underpinning MAFLD are not entirely understood, and there is no effective pharmacological therapy for NAFLD/MAFLD. As a newly discovered form of iron-dependent programmed cell death, ferroptosis can be involved in the development and progression of various chronic diseases, but the pathogenic connections and mechanisms that link MAFLD and ferroptosis have not been fully elucidated. The main characteristics of ferroptosis are the accumulation of lipid peroxides and reactive oxygen species. In this brief narrative review, the mechanisms of ferroptosis and its putative pathogenic role in MAFLD are discussed to highlight potential new research directions and ideas for the prevention and treatment of MAFLD.
非酒精性脂肪性肝病（NAFLD），最近被重新定义和分类为代谢相关脂肪性肝病（MAFLD），其发病率日益增高，已成为全球性的公共卫生问题。迄今为止，MAFLD 的发病机制尚不完全清楚，且 NAFLD/MAFLD 也没有有效的药物治疗方法。铁依赖性程序性细胞死亡的一种新发现形式是铁死亡，它可能参与了各种慢性疾病的发生和发展，但 MAFLD 和铁死亡之间的发病关联和机制尚未完全阐明。铁死亡的主要特征是脂质过氧化物和活性氧的积累。在本简要叙述性综述中，讨论了铁死亡的机制及其在 MAFLD 中的潜在致病作用，以突出 MAFLD 的预防和治疗的新的研究方向和思路。
