Zhu Lei, Liang Ruimin, Guo Yawen, Cai Yefeng, Song Fahuan, Hu Yiqun, Liu Yunye, Ge Minghua, Zheng Guowan
Suzhou Medical College of Soochow University, 215123 Suzhou, Jiangsu, China.
Department of Head and Neck Surgery, the Fifth Hospital Affiliated to Wenzhou Medical University, Lishui Central Hospital, 323020 Lishui City, Zhejiang Province, China.
ACS Omega. 2024 Mar 20;9(13):15590-15602. doi: 10.1021/acsomega.4c00373. eCollection 2024 Apr 2.
Anaplastic thyroid cancer (ATC) is one of the most lethal malignant tumors for which there is no effective treatment. There are an increasing number of studies on herbal medicine for treating malignant tumors, and the classic botanical medicine Digitalis and its active ingredients for treating heart failure and arrhythmias have been revealed to have significant antitumor efficacy against a wide range of malignant tumors. However, the main components of Digitalis and the molecular mechanisms of its anti-ATC effects have not been extensively studied. Here, we screened the main components and core targets of Digitalis and verified the relationship between the active components and targets through network pharmacology, molecular docking, and experimental validation. These experiments showed that the active ingredients of Digitalis inhibit ATC cell activity and lead to ATC cell death through the apoptotic pathway.
间变性甲状腺癌（ATC）是最致命的恶性肿瘤之一，目前尚无有效治疗方法。关于治疗恶性肿瘤的草药研究越来越多，经典植物药洋地黄及其治疗心力衰竭和心律失常的活性成分已被发现对多种恶性肿瘤具有显著的抗肿瘤疗效。然而，洋地黄的主要成分及其抗ATC作用的分子机制尚未得到广泛研究。在此，我们筛选了洋地黄的主要成分和核心靶点，并通过网络药理学、分子对接和实验验证来证实活性成分与靶点之间的关系。这些实验表明，洋地黄的活性成分可抑制ATC细胞活性，并通过凋亡途径导致ATC细胞死亡。
