IL-17A/IL-17RA信号传导与全身抗肿瘤反应中微生物稳态的相互作用。
Interplay of IL-17A/IL-17RA signaling with microbial homeostasis in systemic anti-tumoral responses.
作者信息
He Shi-Jun, Zuo Jian-Ping, Lin Ze-Min
机构信息
Laboratory of Immunopharmacology, State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences Shanghai China.
Innovation Research Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine Shanghai China.
出版信息
MedComm (2020). 2024 Apr 7;5(4):e524. doi: 10.1002/mco2.524. eCollection 2024 Apr.
Enteric IL-17RA deficiency leads to gut dysbiosis, consequently initiating the proliferation of tumors at remote locations. The deficiency or blockade of enteric IL-17RA induces the secretion of IL-17A by B cells and Th17 cells in response to microbial signals, resulting in a systemic elevation of IL-17A and fostering the growth of remote tumors. This figure was created with BioRender.com.
肠道IL-17RA缺乏会导致肠道菌群失调，从而引发远处肿瘤的增殖。肠道IL-17RA的缺乏或阻断会诱导B细胞和Th17细胞响应微生物信号分泌IL-17A，导致IL-17A在全身水平升高，并促进远处肿瘤的生长。此图由BioRender.com创建。
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