Oguma N, Kamada N, Kuramoto A, Tanaka K, Misawa S, Testa J R
J Natl Cancer Inst. 1985 May;74(5):1007-13.
Two patients with acute myeloblastic leukemia (AML) with double minute chromosomes (dmins) are described. One patient had dmins in approximately one-third of bone marrow cells examined at diagnosis; no other karyotypic changes were observed. The dmins disappeared when the patient achieved a complete remission. The second patient developed acute leukemia as a second cancer, having previously received radiotherapy and chemotherapy for a breast carcinoma. At the time of diagnosis of AML, the patient exhibited dmins in 12% of bone marrow cells; other complex karyotypic changes were observed. Data on the clinical and cytogenetic features of these cases are compared with those of other reported cases of acute leukemia with dmins. The possible biologic and clinical significance of dmins in acute leukemia is discussed.
本文描述了两名患有急性髓细胞白血病（AML）且伴有双微体染色体（dmins）的患者。一名患者在诊断时所检查的约三分之一骨髓细胞中存在双微体染色体；未观察到其他核型变化。当该患者达到完全缓解时，双微体染色体消失。第二名患者先前因乳腺癌接受过放疗和化疗，之后患急性白血病，作为第二种癌症。在诊断急性髓细胞白血病时，该患者12%的骨髓细胞中出现双微体染色体；还观察到其他复杂的核型变化。将这些病例的临床和细胞遗传学特征数据与其他报道的伴有双微体染色体的急性白血病病例的数据进行了比较。讨论了双微体染色体在急性白血病中可能的生物学和临床意义。
