Stephenson R A, Luft B J, Pedrotti P W, Remington J S
J Natl Cancer Inst. 1985 May;74(5):1067-70.
The effect of zinc on mouse natural killer (NK) cell activity was evaluated. The inhibition of NK cell activity with zinc was dependent on the concentration of zinc added (range tested: 0-40 micrograms zinc/ml) and occurred at both effector-to-target ratios tested. Zinc-induced inhibition of NK activity was observed with the use of peritoneal or splenic effector cells on Toxoplasma gondii-augmented NK activity. Maximal inhibition of activity was noted when zinc was present for the entire assay period. Inhibition was present but less marked with pretreatment of effector cells with zinc. Pretreatment of target cells with zinc had no measurable effect on NK cytotoxicity. Effector-to-target cell binding as measured by single-cell assays was not significantly altered by zinc. These results indicate that zinc is a potent inhibitor of NK activity.
评估了锌对小鼠自然杀伤（NK）细胞活性的影响。锌对NK细胞活性的抑制作用取决于所添加锌的浓度（测试范围：0 - 40微克锌/毫升），并且在所测试的两种效应细胞与靶细胞比例下均会出现。在使用腹膜或脾脏效应细胞针对弓形虫增强的NK活性时，观察到了锌诱导的NK活性抑制。当在整个测定期间都存在锌时，活性受到最大抑制。用锌预处理效应细胞时也存在抑制作用，但不太明显。用锌预处理靶细胞对NK细胞毒性没有可测量的影响。通过单细胞测定法测量的效应细胞与靶细胞结合未因锌而发生显著改变。这些结果表明锌是NK活性的有效抑制剂。
