Department of Animal Science, University of California, Davis, Davis, California, USA.
J Neuroendocrinol. 2024 Jul;36(7):e13385. doi: 10.1111/jne.13385. Epub 2024 Apr 8.
The conserved and multifaceted functions of prolactin (PRL) are coordinated through varied distribution and expression of its cell-surface receptor (PRLR) across a range of tissues and physiological states. The resultant heterogeneous expression of PRLR mRNA and protein across different organs and cell types supports a wide range of PRL-regulated processes including reproduction, lactation, development, and homeostasis. Genetic variation within the PRLR gene also accounts for several phenotypes impacting agricultural production and human pathology. The goal of this review is to highlight the many elements that control differential expression of the PRLR across tissues, and the various phenotypes that exist across species due to variation in the PRLR gene.
催乳素（PRL）的保守和多方面功能通过其细胞表面受体（PRLR）在多种组织和生理状态下的不同分布和表达来协调。PRLR mRNA 和蛋白质在不同器官和细胞类型中的异质表达支持广泛的 PRL 调节过程，包括生殖、哺乳、发育和体内平衡。PRLR 基因内的遗传变异也导致了几种影响农业生产和人类病理学的表型。本综述的目的是强调控制 PRLR 在组织中差异表达的许多因素，以及由于 PRLR 基因的变异导致的不同物种之间存在的各种表型。
