Schneider M, Rathaus M, Shapira J, Bernheim J
Nephron. 1985;40(2):152-4. doi: 10.1159/000183452.
The role played by renal prostaglandins E2 (PGE2) and F2 alpha (PGF 2 alpha) in the modification of sodium homeostasis in chronic renal failure (CFR) was studied. The 24-hour urinary excretion of PGE2 and PGF2 alpha was measured before and after 5 days of a diet containing less than 20 mmol/day of sodium in 6 patients with CRF. At the end of this period, an acute sodium load (77 mmol/h of NaCl for 4 h) was administered and prostaglandins measured in hourly urine collections. In contrast to the findings previously reported in normal subjects, PGE2 and PGF2 alpha decreased with the low-sodium diet. The ratio PGE2/PGF2 alpha (reflecting the activity of the enzyme PGE2-9-ketoreductase) was greatly increased and did not change with the low-sodium diet. The acute sodium load induced an increase in urinary prostaglandins. The results suggest that prostaglandins may contribute to natriuresis in CRF, under basal conditions, after a short-term sodium depletion and in response to an acute sodium load. The changes in prostaglandin excretion in CRF could be related to decreased activity of PGE2-9-ketoreductase.
