二阶运动补偿回波平面心脏扩散加权磁共振成像：压缩感知编码的效用

Second-Order Motion-Compensated Echo-Planar Cardiac Diffusion-Weighted MRI: Usefulness of Compressed Sensitivity Encoding.

作者信息

Chen Rui, Luo Ruohong, Xu Yongzhou, Ou Jiehao, Li Xiaodan, Yang Yuelong, Cao Liqi, Wu Zhigang, Luo Wei, Liu Hui

机构信息

Department of Radiology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.

Guangdong Provincial Key Laboratory of Artificial Intelligence in Medical Image Analysis and Application, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, Guangdong, China.

出版信息

J Magn Reson Imaging. 2025 Jan;61(1):305-318. doi: 10.1002/jmri.29383. Epub 2024 Apr 8.

DOI:10.1002/jmri.29383

PMID:38587265

Abstract

BACKGROUND

Cardiac diffusion-weighted imaging (DWI) using second-order motion-compensated spin echo (M2C) can provide noninvasive in-vivo microstructural assessment, but limited by relatively low signal-to-noise ratio (SNR). Echo-planar imaging (EPI) with compressed sensitivity encoding (EPICS) could address these issues.

PURPOSE

To combine M2C DWI and EPCIS (M2C EPICS DWI), and compare image quality for M2C DWI.

STUDY TYPE

Prospective.

POPULATION

Ten ex-vivo hearts, 10 healthy volunteers (females, 5 [50%]; mean ± SD of age, 25 ± 4 years), and 12 patients with diseased hearts (female, 1 [8.3%]; mean ± SD of age, 44 ± 16 years; including coronary artery heart disease, congenital heart disease, dilated cardiomyopathy, amyloidosis, and myocarditis).

FIELD STRENGTH/SEQUENCE: 3-T, M2C EPICS DWI, and M2C DWI.

ASSESSMENT

The apparent SNR (aSNR) and the rating scores were used to evaluate and compared image quality of all three groups. The aSNR was calculated using , and the myocardium was segmented manually. Three observers independently rated subjective image quality using a 5-point Likert scale.

STATISTICAL TESTS

Bland-Altman analysis and paired t-tests. The threshold for statistical significance was set at P < 0.05.

RESULTS

In healthy volunteers, the aSNR with a b-value of 450 s/mm acquired by M2C EPICS DWI was significantly higher than M2C DWI at in-plane resolutions of 3.0 × 3.0, 2.5 × 2.5, and 2.0 × 2.0 mm. In patients with diseased hearts, the aSNR ofM2C EPICS DWI was also significantly higher than that for M2C DWI (bias of M2C EPICS-M2C = 1.999, 95% limits of agreement, 0.362 to 3.636; mean ± SD, 7.80 ± 1.37 vs. 5.80 ± 0.81). The ADC values of M2C EPICS was significantly higher than M2C DWI in in-vivo hearts. Over 80% of the images with rating scores for M2C EPICS DWI were higher than M2C DWI in in-vivo hearts.

DATA CONCLUSION

Cardiac imaging by M2C EPICS DWI may demonstrate better overall image quality and higher aSNR than M2C DWI.

EVIDENCE LEVEL

2 TECHNICAL EFFICACY: Stage 1.

摘要

背景

使用二阶运动补偿自旋回波（M2C）的心脏扩散加权成像（DWI）可提供无创的体内微观结构评估，但受相对较低的信噪比（SNR）限制。具有压缩感知编码（EPICS）的回波平面成像（EPI）可解决这些问题。

目的

将M2C DWI与EPCIS（M2C EPICS DWI）相结合，并比较M2C DWI的图像质量。

研究类型

前瞻性研究。

研究对象

10个离体心脏、10名健康志愿者（女性5名[50%]；年龄均值±标准差，25±4岁）和12名患心脏疾病的患者（女性1名[8.3%]；年龄均值±标准差，44±16岁；包括冠状动脉心脏病、先天性心脏病、扩张型心肌病、淀粉样变性和心肌炎）。

场强/序列：3-T，M2C EPICS DWI和M2C DWI。

评估

使用表观信噪比（aSNR）和评分来评估和比较所有三组的图像质量。aSNR使用计算，心肌通过手动分割。三名观察者使用5点李克特量表独立对主观图像质量进行评分。

统计检验

Bland-Altman分析和配对t检验。统计学显著性阈值设定为P<0.05。

结果

在健康志愿者中，在平面分辨率为3.0×3.0、2.5×2.5和2.0×2.0 mm时，M2C EPICS DWI获得的b值为450 s/mm²时的aSNR显著高于M2C DWI。在患心脏疾病的患者中，M2C EPICS DWI的aSNR也显著高于M2C DWI（M2C EPICS - M2C的偏差 = 1.999，95%一致性界限，0.362至3.636；均值±标准差，7.80±1.37对5.80±0.81）。在体内心脏中，M2C EPICS的表观扩散系数（ADC）值显著高于M2C DWI。在体内心脏中，超过80%的M2C EPICS DWI评分图像高于M2C DWI。